Stroke is the second most common cause of death worldwide and a major cause of acquired
disability in adults. Despite tremendous progress in understanding the pathophysiology of …

Over the past several decades, there have been substantial advances in our knowledge of
the pathophysiology of stroke. Understanding the benefits of timely reperfusion has led to …

Clearing cellular debris after brain injury represents an important mechanism in regaining
tissue homeostasis and promoting functional recovery. Triggering receptor expressed on …

Psychological stress contributes to the development of clinical depression. This has
prompted many preclinical studies to investigate the neurobiology of this relationship …

Brain infarction causes tissue death by ischemia due to occlusion of the cerebral vessels
and recent work has shown that post stroke inflammation contributes significantly to the …

For the last two decades, researchers have placed hopes in a new era in which a
combination of reperfusion and neuroprotection would revolutionize the treatment of stroke …

Minocycline is a semi-synthetic, second-generation tetracycline analog which is effectively
crossing the blood–brain barrier, effective against gram-positive and-negative infections. In …

Stroke is a frequent cause of long-term disability and death worldwide. Ischemic stroke is
more commonly encountered compared to hemorrhagic stroke, and leads to tissue death by …

One of the hallmarks of stroke pathophysiology is the widespread death of many different
types of brain cells. As our understanding of the complex disease that is stroke has grown, it …

By studying the literature about tetracyclines (TCs), it becomes clearly evident that TCs are
very dynamic molecules. In some cases, their structure-activity-relationship (SAR) are well …