[HTML][HTML] Unexpected evidence for active brown adipose tissue in adult humans
J Nedergaard, T Bengtsson… - American Journal of …, 2007 - journals.physiology.org
The contention that brown adipose tissue is absent in adult man has meant that processes
attributed to active brown adipose tissue in experimental animals (mainly rodents), ie …
attributed to active brown adipose tissue in experimental animals (mainly rodents), ie …
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
Reproducible science requires transparent reporting. The ARRIVE guidelines (Animal
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …
Research: Reporting of In Vivo Experiments) were originally developed in 2010 to improve …
[HTML][HTML] Reporting animal research: Explanation and elaboration for the ARRIVE guidelines 2.0
Improving the reproducibility of biomedical research is a major challenge. Transparent and
accurate reporting is vital to this process; it allows readers to assess the reliability of the …
accurate reporting is vital to this process; it allows readers to assess the reliability of the …
Mice anesthesia, analgesia, and care, Part I: anesthetic considerations in preclinical research
S Gargiulo, A Greco, M Gramanzini, S Esposito… - ILAR …, 2012 - academic.oup.com
Animal experiments are necessary for a better understanding of diseases and for
developing new therapeutic strategies. The mouse (Mus musculus) is currently the most …
developing new therapeutic strategies. The mouse (Mus musculus) is currently the most …
Slow TCA flux and ATP production in primary solid tumours but not metastases
Tissues derive ATP from two pathways—glycolysis and the tricarboxylic acid (TCA) cycle
coupled to the electron transport chain. Most energy in mammals is produced via TCA …
coupled to the electron transport chain. Most energy in mammals is produced via TCA …
[PDF][PDF] The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type
MO Yuneva, TWM Fan, TD Allen, RM Higashi… - Cell metabolism, 2012 - cell.com
The altered metabolism of tumors has been considered a target for anticancer therapy.
However, the relationship between distinct tumor-initiating lesions and anomalies of tumor …
However, the relationship between distinct tumor-initiating lesions and anomalies of tumor …
[HTML][HTML] Inhibition of mitochondrial fission prevents cell cycle progression in lung cancer
Mitochondria exist in dynamic networks that undergo fusion and fission. Mitochondrial fusion
and fission are mediated by several GTPases in the outer mitochondrial membrane, notably …
and fission are mediated by several GTPases in the outer mitochondrial membrane, notably …
Optical metabolic imaging identifies glycolytic levels, subtypes, and early-treatment response in breast cancer
Abnormal cellular metabolism is a hallmark of cancer, yet there is an absence of quantitative
methods to dynamically image this powerful cellular function. Optical metabolic imaging …
methods to dynamically image this powerful cellular function. Optical metabolic imaging …
Brown adipose tissue in adult humans: a metabolic renaissance
P Lee, MM Swarbrick, KKY Ho - Endocrine reviews, 2013 - academic.oup.com
Brown adipose tissue (BAT) plays a key role in energy homeostasis and thermogenesis in
animals, conferring protection against diet-induced obesity and hypothermia through the …
animals, conferring protection against diet-induced obesity and hypothermia through the …
[HTML][HTML] The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition
Adenocarcinoma (ADC) and squamous cell carcinoma (SqCC) are the two predominant
subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological …
subtypes of non-small cell lung cancer (NSCLC) and are distinct in their histological …