Fusion proteins play an essential role in the biosciences but suffer from several key
limitations, including the requirement for N-to-C terminal ligation, incompatibility of …

Molecular imaging has witnessed a tremendous change over the last decade. Growing
interest and emphasis are placed on this specialized technology represented by developing …

The need to study dynamic biologic processes in intact small-animal models of disease has
stimulated the development of high-resolution nuclear imaging methods. These methods are …

Artificial manipulation of antibody genes has facilitated the production of several unique
recombinant antibody formats, which have highly important therapeutic and biotechnological …

Translational research is changing the practice of modern medicine and the way in which
health problems are approached and solved. The use of small-animal models in basic and …

Bispecific antibodies combine the specificity of two antibodies into one molecule. During the
past two decades, advancement in protein engineering enabled the development of more …

Background—Matrix metalloproteinase (MMP) activation plays a key role in vascular
remodeling. RP782 is a novel indium 111In–labeled tracer with specificity for activated …

Introduction Doxorubicin, a frontline chemotherapeutic agent, limited by its cardiotoxicity and
other tissue toxicities, was conjugated to N-terminal DTPA-modified polyglutamic acid (D …

Molecular imaging relies on the development of sensitive and specific probes coupled with
imaging hardware and software to provide information about the molecular status of a …

Background—The receptor for advanced glycation end products (RAGE) is implicated in the
development and progression of atherosclerosis. We tested the hypothesis that 99mTc …