Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes

C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - ASPET
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …

Peptide-based imaging agents for cancer detection

X Sun, Y Li, T Liu, Z Li, X Zhang, X Chen - Advanced drug delivery reviews, 2017 - Elsevier
Selective receptor-targeting peptide based agents have attracted considerable attention in
molecular imaging of tumor cells that overexpress corresponding peptide receptors due to …

GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting

M Körner, M Stöckli, B Waser… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Peptide hormone receptors overexpressed in human tumors, such as somatostatin
receptors, can be used for in vivo targeting for diagnostic and therapeutic purposes. A novel …

[HTML][HTML] Radiolabeled peptides: valuable tools for the detection and treatment of cancer

M Fani, HR Maecke, SM Okarvi - Theranostics, 2012 - ncbi.nlm.nih.gov
Human cancer cells overexpress many peptide receptors as molecular targets.
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …

Peptide-based probes for targeted molecular imaging

S Lee, J Xie, X Chen - Biochemistry, 2010 - ACS Publications
Targeted molecular imaging techniques have become indispensable tools in modern
diagnostics because they provide accurate and specific diagnosis of disease information …

Peptides and peptide hormones for molecular imaging and disease diagnosis

S Lee, J Xie, X Chen - Chemical reviews, 2010 - ACS Publications
Molecular imaging techniques are now indispensable tools in modern diagnostics, because
they are highly specific and can provide biological information at the molecular level in living …

Glucagon-like peptide-1 receptor imaging for localization of insulinomas

E Christ, D Wild, F Forrer, M Brandle… - The Journal of …, 2009 - academic.oup.com
Context: The surgical removal of insulinomas is hampered by difficulties to localize it using
conventional radiological procedures. Recently these tumors were shown to exhibit a very …

Radiopharmaceutical development of radiolabelled peptides

M Fani, HR Maecke - European journal of nuclear medicine and …, 2012 - Springer
Receptor targeting with radiolabelled peptides has become very important in nuclear
medicine and oncology in the past few years. The overexpression of many peptide receptors …

Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications

B Manandhar, JM Ahn - Journal of medicinal chemistry, 2015 - ACS Publications
Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in
glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin …

Glucagon-like peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant insulinomas

D Wild, E Christ, ME Caplin… - Journal of Nuclear …, 2011 - Soc Nuclear Med
Glucagon-like peptide-1 (GLP-1) receptor imaging is superior to somatostatin receptor
subtype 2 (sst2) imaging in localizing benign insulinomas. Here, the role of GLP-1 and sst2 …