Glucagon-like peptide-1 and its class BG protein–coupled receptors: a long march to therapeutic successes
C De Graaf, D Donnelly, D Wootten, J Lau… - Pharmacological …, 2016 - ASPET
The glucagon-like peptide (GLP)-1 receptor (GLP-1R) is a class BG protein–coupled
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
receptor (GPCR) that mediates the action of GLP-1, a peptide hormone secreted from three …
Peptide-based imaging agents for cancer detection
Selective receptor-targeting peptide based agents have attracted considerable attention in
molecular imaging of tumor cells that overexpress corresponding peptide receptors due to …
molecular imaging of tumor cells that overexpress corresponding peptide receptors due to …
GLP-1 receptor expression in human tumors and human normal tissues: potential for in vivo targeting
M Körner, M Stöckli, B Waser… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Peptide hormone receptors overexpressed in human tumors, such as somatostatin
receptors, can be used for in vivo targeting for diagnostic and therapeutic purposes. A novel …
receptors, can be used for in vivo targeting for diagnostic and therapeutic purposes. A novel …
[HTML][HTML] Radiolabeled peptides: valuable tools for the detection and treatment of cancer
M Fani, HR Maecke, SM Okarvi - Theranostics, 2012 - ncbi.nlm.nih.gov
Human cancer cells overexpress many peptide receptors as molecular targets.
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …
Radiolabeled peptides that bind with high affinity and specificity to the receptors on tumor …
Peptide-based probes for targeted molecular imaging
Targeted molecular imaging techniques have become indispensable tools in modern
diagnostics because they provide accurate and specific diagnosis of disease information …
diagnostics because they provide accurate and specific diagnosis of disease information …
Peptides and peptide hormones for molecular imaging and disease diagnosis
Molecular imaging techniques are now indispensable tools in modern diagnostics, because
they are highly specific and can provide biological information at the molecular level in living …
they are highly specific and can provide biological information at the molecular level in living …
Glucagon-like peptide-1 receptor imaging for localization of insulinomas
Context: The surgical removal of insulinomas is hampered by difficulties to localize it using
conventional radiological procedures. Recently these tumors were shown to exhibit a very …
conventional radiological procedures. Recently these tumors were shown to exhibit a very …
Radiopharmaceutical development of radiolabelled peptides
M Fani, HR Maecke - European journal of nuclear medicine and …, 2012 - Springer
Receptor targeting with radiolabelled peptides has become very important in nuclear
medicine and oncology in the past few years. The overexpression of many peptide receptors …
medicine and oncology in the past few years. The overexpression of many peptide receptors …
Glucagon-like peptide-1 (GLP-1) analogs: recent advances, new possibilities, and therapeutic implications
B Manandhar, JM Ahn - Journal of medicinal chemistry, 2015 - ACS Publications
Glucagon-like peptide-1 (GLP-1) is an incretin that plays important physiological roles in
glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin …
glucose homeostasis. Produced from intestine upon food intake, it stimulates insulin …
Glucagon-like peptide-1 versus somatostatin receptor targeting reveals 2 distinct forms of malignant insulinomas
Glucagon-like peptide-1 (GLP-1) receptor imaging is superior to somatostatin receptor
subtype 2 (sst2) imaging in localizing benign insulinomas. Here, the role of GLP-1 and sst2 …
subtype 2 (sst2) imaging in localizing benign insulinomas. Here, the role of GLP-1 and sst2 …