Multimodality molecular imaging of tumor angiogenesis
Molecular imaging is a key component of 21st-century cancer management. The vascular
endothelial growth factor (VEGF)/VEGF receptor signaling pathway and integrin α v β 3, a …
endothelial growth factor (VEGF)/VEGF receptor signaling pathway and integrin α v β 3, a …
Anti-angiogenic cancer therapy based on integrin αvβ3 antagonism
Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is a
fundamental process during cancer progression. Anti-angiogenic strategies have been …
fundamental process during cancer progression. Anti-angiogenic strategies have been …
PET/MRI dual-modality tumor imaging using arginine-glycine-aspartic (RGD)–conjugated radiolabeled iron oxide nanoparticles
The purpose of this study was to develop a bifunctional iron oxide (IO) nanoparticle probe for
PET and MRI scans of tumor integrin αvβ3 expression. Methods: Polyaspartic acid (PASP) …
PET and MRI scans of tumor integrin αvβ3 expression. Methods: Polyaspartic acid (PASP) …
Quantitative PET of EGFR expression in xenograft-bearing mice using 64Cu-labeled cetuximab, a chimeric anti-EGFR monoclonal antibody
Purpose Cetuximab, a chimeric monoclonal antibody targeting epidermal growth factor
receptor (EGFR) on the surface of cancer cells, was approved by the FDA to treat patients …
receptor (EGFR) on the surface of cancer cells, was approved by the FDA to treat patients …
[HTML][HTML] Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide
F Kreppel, S Kochanek - Molecular Therapy, 2008 - cell.com
The chemical modification of adenovirus (Ad) gene transfer vectors with synthetic polymers
is a promising strategy for overcoming typical in vivo hurdles associated with Ad-mediated …
is a promising strategy for overcoming typical in vivo hurdles associated with Ad-mediated …
PET of vascular endothelial growth factor receptor expression
For solid tumors and metastatic lesions, tumor vascularity is a critical factor in assessing
response to therapy. Here we report the first example, to our knowledge, of 64Cu-labeled …
response to therapy. Here we report the first example, to our knowledge, of 64Cu-labeled …
[HTML][HTML] Are quantum dots ready for in vivo imaging in human subjects?
Nanotechnology has the potential to profoundly transform the nature of cancer diagnosis
and cancer patient management in the future. Over the past decade, quantum dots (QDs) …
and cancer patient management in the future. Over the past decade, quantum dots (QDs) …
Imaging of integrins as biomarkers for tumor angiogenesis
The integrin family plays important roles during tumor angiogenesis, the formation of new
blood vessels from pre-existing vasculature. Traditional structural and functional imaging …
blood vessels from pre-existing vasculature. Traditional structural and functional imaging …
[HTML][HTML] Targeted delivery of siRNA
Therapeutic application of siRNA requires delivery to the correct intracellular location, to
interact with the RNAi machinery within the target cell, within the target tissue responsible for …
interact with the RNAi machinery within the target cell, within the target tissue responsible for …
Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modified lipid–polymer hybrid nanoparticles
Z Yang, X Luo, X Zhang, J Liu, Q Jiang - Biomedical Materials, 2013 - iopscience.iop.org
Lipid–polymer hybrid nanoparticles (NPs) combining the positive attributes of both
liposomes and polymeric NPs are increasingly being considered as promising candidates to …
liposomes and polymeric NPs are increasingly being considered as promising candidates to …