Matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is an emerging
analytical tool for the analysis of molecules with molar masses below 1,000 Da; that is, small …

Alteration in mitochondrial transmembrane potential (ΔΨm) is an important characteristic of
cancer. The observation that the enhanced negative mitochondrial potential is prevalent in …

The alkyltriphenylphosphonium (TPP) group is the most widely used vector targeted to
mitochondria. Previously, the length of the alkyl linker was varied as well as structural …

Purpose Mitochondrial dysfunction has been attributed a critical role in the etiology and
pathogenesis of numerous diseases, and is manifested by alterations of the organelle's …

In this report, we present the synthesis and evaluation of six new 64Cu-labeled
triphenylphosphonium (TPP) cations. Biodistribution studies were performed using the …

Dual mitochondria targeting fluorescent F16–TPP analogues were designed and
synthesized. Uptake and cytotoxicity studies indicate that FF16 and FF16–TPP, two …

This report presents synthesis and evaluation of the 64Cu-labeled triphenylphosphonium
(TPP) cations as new radiotracers for imaging tumors by positron emission tomography …

Radiolabeled lipophilic cationic compounds, such as 18F-labeled phosphonium salt,
accumulate in the mitochondria through a negative inner transmembrane potential. The …

INTRODUCTION: Established radiotracers for positron emission tomography (PET)
myocardial perfusion study are commonly labeled with short-lived radio-isotopes that limit …

Lipophilic cations such as phosphonium salts penetrate the hydrophobic barriers of the
plasma and mitochondrial membranes and accumulate in mitochondria in response to the …