Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Animal poisons and venoms are comprised of different classes of molecules displaying wide-
ranging pharmacological activities. This review aims to provide an in-depth view of toxin …

In contrast to almost all other brain tumors, diffuse gliomas infiltrate extensively in the
neuropil. This growth pattern is a major factor in therapeutic failure. Diffuse infiltrative glioma …

Scorpions are well known for their dangerous stings that can result in severe consequences
for human beings, including death. Neurotoxins present in their venoms are responsible for …

The growing research interest in nanomedicine for the treatment of cancer and inflammatory-
related pathologies is yielding encouraging results. Unfortunately, enthusiasm is tempered …

Toward the goal of developing an optical imaging contrast agent that will enable surgeons to
intraoperatively distinguish cancer foci from adjacent normal tissue, we developed a …

Targeted therapies for cancer is a rapidly advancing field, but the identification of tumor-
specific ligands has proven difficult. Chlorotoxin (CTX) is a small, 36 amino acid neurotoxin …

BACKGROUND Fluorescence-guided surgery (FGS) can improve extent of resection in
gliomas. Tozuleristide (BLZ-100), a near-infrared imaging agent composed of the peptide …

The constant changes in cancer cell bioenergetics are widely known as metabolic
reprogramming. Reprogramming is a process mediated by multiple factors, including …

Chlorotoxin is a small 36 amino-acid peptide identified from the venom of the scorpion
Leiurus quinquestriatus. Initially, chlorotoxin was used as a pharmacological tool to …