Drugs and alcohol: treating and preventing abuse, addiction and their medical consequences

ND Volkow, TK Li - Pharmacology & therapeutics, 2005 - Elsevier
Recent advances in the fields of genetics, molecular biology, behavioral
neuropharmacology, and brain imaging have dramatically changed our understanding of …

Radiosynthesis, preclinical, and clinical positron emission tomography studies of carbon-11 labeled endogenous and natural exogenous compounds

A Shegani, S Kealey, F Luzi, F Basagni… - Chemical …, 2022 - ACS Publications
The presence of positron emission tomography (PET) centers at most major hospitals
worldwide, along with the improvement of PET scanner sensitivity and the introduction of …

Continuous, real-time monitoring of cocaine in undiluted blood serum via a microfluidic, electrochemical aptamer-based sensor

JS Swensen, Y Xiao, BS Ferguson… - Journal of the …, 2009 - ACS Publications
The development of a biosensor system capable of continuous, real-time measurement of
small-molecule analytes directly in complex, unprocessed aqueous samples has been a …

DARK classics in chemical neuroscience: cocaine

LR Drake, PJH Scott - ACS chemical neuroscience, 2018 - ACS Publications
In this Review, we consider the story of cocaine from its humble origins in South America to
its status as one of the most abused substances in 21st century society. The synthesis and …

In Vivo mouse imaging and spectroscopy in drug discovery

N Beckmann, R Kneuer, HU Gremlich… - NMR in biomedicine …, 2007 - Wiley Online Library
Imaging modalities such as micro‐computed tomography (micro‐CT), micro‐positron
emission tomography (micro‐PET), high‐resolution MRI, optical imaging, and high …

The integration of positron emission tomography with magnetic resonance imaging

SR Cherry, AY Louie, RE Jacobs - Proceedings of the IEEE, 2008 - ieeexplore.ieee.org
A number of laboratories and companies are currently exploring the development of
integrated imaging systems for magnetic resonance imaging (MRI) and positron emission …

Cytotoxicity, genotoxicity, transplacental transfer and tissue disposition in pregnant rats mediated by nanoparticles: the case of magnetic core mesoporous silica …

SR Pinto, E Helal-Neto, F Paumgartten… - Artificial cells …, 2018 - Taylor & Francis
Whether in the cosmetic or as therapeutic, the use of nanoparticles has been increasing and
taking on global proportion. However, there are few studies about the physical potential of …

Fate of systemically administered cocaine in nonhuman primates treated with the dAd5GNE anticocaine vaccine

MJ Hicks, SM Kaminsky, BP De… - Human Gene …, 2014 - liebertpub.com
Cocaine use disorders are mediated by the cocaine blockade of the dopamine transporter in
the central nervous system (CNS). On the basis of the concept that these effects could be …

Cocaine and its metabolites in the placenta: a systematic review of the literature

N De Giovanni, D Marchetti - Reproductive toxicology, 2012 - Elsevier
It is clear that cocaine and cocaine metabolites are present in the placenta and may harm
the fetus. The results of the experimental manipulation of cocaine exposure are not reported …

Simultaneous PET imaging of P-glycoprotein inhibition in multiple tissues in the pregnant nonhuman primate

S Eyal, FS Chung, M Muzi, JM Link… - Journal of Nuclear …, 2009 - Soc Nuclear Med
Studies in rodents indicate that the disruption of P-glycoprotein (P-gp) function increases
drug distribution into the developing fetus and organs such as the brain. To simultaneously …