Molecular hybrids: A five-year survey on structures of multiple targeted hybrids of protein kinase inhibitors for cancer therapy

OM Soltan, ME Shoman, SA Abdel-Aziz… - European Journal of …, 2021 - Elsevier
Protein kinases have grown over the past few years as a crucial target for different cancer
types. With the multifactorial nature of cancer, and the fast development of drug resistance …

[HTML][HTML] Affibody molecules as targeting vectors for PET imaging

V Tolmachev, A Orlova - Cancers, 2020 - mdpi.com
Affibody molecules are small (58 amino acids) engineered scaffold proteins that can be
selected to bind to a large variety of proteins with a high affinity. Their small size and high …

[HTML][HTML] Measuring HER2-receptor expression in metastatic breast cancer using [68Ga] ABY-025 Affibody PET/CT

J Sörensen, I Velikyan, D Sandberg, A Wennborg… - Theranostics, 2016 - ncbi.nlm.nih.gov
Purpose: Positron Emission Tomography (PET) imaging of HER2 expression could
potentially be used to select patients for HER2-targed therapy, predict response based on …

αVβ3 Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug

N Graf, DR Bielenberg, N Kolishetti, C Muus… - ACS …, 2012 - ACS Publications
Targeted delivery of therapeutics to tumor neovasculature is potentially a powerful approach
for selective cancer treatment. Integrins are heterodimeric transmembrane proteins involved …

Targeted nuclear medicine. Seek and destroy

VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …

Phase I trial of the positron-emitting Arg-Gly-Asp (RGD) peptide radioligand 18F-AH111585 in breast cancer patients

LM Kenny, RC Coombes, I Oulie… - Journal of nuclear …, 2008 - Soc Nuclear Med
The integrin αvβ3 receptor is upregulated on tumor cells and endothelium and plays
important roles in angiogenesis and metastasis. Arg-Gly-Asp (RGD) peptide ligands have …

Targeting RGD recognizing integrins: drug development, biomaterial research, tumor imaging and targeting

A Meyer, J Auernheimer, A Modlinger… - Current …, 2006 - ingentaconnect.com
Integrins constitute an important class of cell adhesion receptors responsible not only for cell-
matrix adhesion but also for signaling bidirectionally across the membrane. Integrins are …

[HTML][HTML] Imaging using radiolabelled targeted proteins: Radioimmunodetection and beyond

J Garousi, A Orlova, FY Frejd, V Tolmachev - EJNMMI radiopharmacy and …, 2020 - Springer
The use of radiolabelled antibodies was proposed in 1970s for staging of malignant
tumours. Intensive research established chemistry for radiolabelling of proteins and …

TRAP, a Powerful and Versatile Framework for Gallium‐68 Radiopharmaceuticals

J Notni, J Šimeček, P Hermann, HJ Wester - Chemistry–A European …, 2011 - infona.pl
A veritable gallium TRAP: Triazacyclononane‐phosphinic acid chelators (TRAP) form highly
stable complexes with Ga 3+(see figure) extremely efficiently over a wide pH range. Homo …

The emerging role of radionuclide molecular imaging of HER2 expression in breast cancer

V Tolmachev, A Orlova, J Sörensen - Seminars in cancer biology, 2021 - Elsevier
Targeting of human epidermal growth factor type 2 (HER2) using monoclonal antibodies,
antibody-drug conjugates and tyrosine kinase inhibitors extends survival of patients with …