Molecular imaging in drug development
JK Willmann, N Van Bruggen, LM Dinkelborg… - Nature reviews Drug …, 2008 - nature.com
Molecular imaging can allow the non-invasive assessment of biological and biochemical
processes in living subjects. Such technologies therefore have the potential to enhance our …
processes in living subjects. Such technologies therefore have the potential to enhance our …
Methods and challenges in quantitative imaging biomarker development
RG Abramson, KR Burton, JY John-Paul, EM Scalzetti… - Academic radiology, 2015 - Elsevier
Academic radiology is poised to play an important role in the development and
implementation of quantitative imaging (QI) tools. This article, drafted by the Association of …
implementation of quantitative imaging (QI) tools. This article, drafted by the Association of …
microPET-based biodistribution of quantum dots in living mice
ML Schipper, Z Cheng, SW Lee… - Journal of Nuclear …, 2007 - Soc Nuclear Med
This study evaluates the quantitative biodistribution of commercially available CdSe
quantum dots (QD) in mice. Methods: 64Cu-Labeled 800-or 525-nm emission wavelength …
quantum dots (QD) in mice. Methods: 64Cu-Labeled 800-or 525-nm emission wavelength …
[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity
W Kim, TM Le, L Wei, S Poddar… - Proceedings of the …, 2016 - National Acad Sciences
Deoxycytidine kinase (dCK), a rate-limiting enzyme in the cytosolic deoxyribonucleoside
(dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) …
(dN) salvage pathway, is an important therapeutic and positron emission tomography (PET) …
Kinetic analysis of 3′-deoxy-3′-18F-fluorothymidine in patients with gliomas
M Muzi, AM Spence, F O'Sullivan… - Journal of Nuclear …, 2006 - Soc Nuclear Med
3′-Deoxy-3′-fluorothymidine (FLT), a thymidine analog, is under investigation for
monitoring cellular proliferation in gliomas, a potential measure of disease progression and …
monitoring cellular proliferation in gliomas, a potential measure of disease progression and …
Small-animal preclinical nuclear medicine instrumentation and methodology
DJ Rowland, SR Cherry - Seminars in nuclear medicine, 2008 - Elsevier
Molecular medicine enhances the clinician's ability to accurately diagnose and treat
disease, and many technological advances in diverse fields have made the translation of …
disease, and many technological advances in diverse fields have made the translation of …
Reproducibility of 18F-FDG microPET studies in mouse tumor xenografts
M Dandekar, JR Tseng, SS Gambhir - Journal of nuclear …, 2007 - Soc Nuclear Med
18F-FDG has been used to image mouse xenograft models with small-animal PET for
therapy response. However, the reproducibility of serial scans has not been determined. The …
therapy response. However, the reproducibility of serial scans has not been determined. The …
Multimodality molecular imaging of glioblastoma growth inhibition with vasculature-targeting fusion toxin VEGF121/rGel
AR Hsu, W Cai, A Veeravagu… - Journal of Nuclear …, 2007 - Soc Nuclear Med
Vascular endothelial growth factor A (VEGF-A) and its receptors, Flt-1/FLT-1 (VEGFR-1) and
Flk-1/KDR (VEGFR-2), are key regulators of tumor angiogenesis and tumor growth. The …
Flk-1/KDR (VEGFR-2), are key regulators of tumor angiogenesis and tumor growth. The …
PET hypoxia imaging with FAZA: reproducibility at baseline and during fractionated radiotherapy in tumour-bearing mice
M Busk, LS Mortensen, M Nordsmark… - European journal of …, 2013 - Springer
Purpose Tumour hypoxia is linked to treatment resistance. Positron emission tomography
(PET) using hypoxia tracers such as fluoroazomycin arabinoside (FAZA) may allow …
(PET) using hypoxia tracers such as fluoroazomycin arabinoside (FAZA) may allow …
Conventional and novel PET tracers for imaging in oncology in the era of molecular therapy
MA Pantaleo, M Nannini, A Maleddu, S Fanti… - Cancer treatment …, 2008 - Elsevier
In the last ten years, the development of several novel targeted drugs and the refinement of
state of the art technologies such as the genomics and proteomics and their introduction to …
state of the art technologies such as the genomics and proteomics and their introduction to …