Traumatic brain injury (TBI) affects an estimated 1.7 million people in the United States and
is a contributing factor to one third of all injury related deaths annually. According to the …

The need to study dynamic biologic processes in intact small-animal models of disease has
stimulated the development of high-resolution nuclear imaging methods. These methods are …

Metabolically, the brain is a highly active organ that relies almost exclusively on glucose as
its energy source. According to the astrocyte-to-neuron lactate shuttle hypothesis, glucose is …

Quantitative assessment of cerebral glucose consumption rate (CMRglc) and tricarboxylic
acid cycle flux (VTCA) is crucial for understanding neuroenergetics under …

Positron emission tomography (PET) is a minimally invasive imaging procedure with a wide
range of clinical and research applications. PET allows for the three-dimensional mapping of …

Brains are among the most energetically costly tissues in the mammalian body. 1 This is
predominantly caused by expensive neurons with high glucose demands. 2 Across …

GLUT4 in muscle and adipose tissue is important in maintaining glucose homeostasis.
However, the role of insulin-responsive GLUT4 in the central nervous system has not been …

Background: A suitable, effective and free of complications anesthetic protocol is very
important in experimental studies on animal models since it could bias the outcome of a trial …

The biologic mechanisms involved in the intratumoral heterogeneous distribution of 18F-
FDG have not been fully investigated. To clarify factors inducing heterogeneous 18F-FDG …

Cerebrovascular P-glycoprotein (P-gp) acts at the blood–brain barrier (BBB) as an active
cell membrane efflux pump for several endogenous and exogenous compounds. Age …