Matching chelators to radiometals for radiopharmaceuticals
Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …
properly harnessed, these have valuable emission properties that can be used for …
Targeted nuclear medicine. Seek and destroy
VM Tolmachev, VI Chernov… - Russian Chemical …, 2022 - iopscience.iop.org
The targeted delivery of radionuclides to tumours holds great promise for diagnosis and
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
treatment of malignant neoplasms. The development of scaffold proteins has significantly …
[HTML][HTML] Development of antibody immuno-PET/SPECT radiopharmaceuticals for imaging of oncological disorders—an update
J Dewulf, K Adhikari, C Vangestel, TVD Wyngaert… - Cancers, 2020 - mdpi.com
Positron emission tomography (PET) and single-photon emission computed tomography
(SPECT) are molecular imaging strategies that typically use radioactively labeled ligands to …
(SPECT) are molecular imaging strategies that typically use radioactively labeled ligands to …
[HTML][HTML] Development of an imaging-guided CEA-pretargeted radionuclide treatment of advanced colorectal cancer: first clinical results
R Schoffelen, OC Boerman, DM Goldenberg… - British journal of …, 2013 - nature.com
Background: Radiolabelled antibody targeting of cancer is limited by slow blood clearance.
Pretargeting with a non-radiolabelled bispecific monoclonal antibody (bsMAb) followed by a …
Pretargeting with a non-radiolabelled bispecific monoclonal antibody (bsMAb) followed by a …
Electron-and positron-emitting radiolanthanides for therapy: aspects of dosimetry and production
H Uusijärvi, P Bernhardt, F Rösch… - Journal of Nuclear …, 2006 - Soc Nuclear Med
All lanthanides have similar chemical properties regarding labeling. Therefore,
radiolanthanides that have been used for therapy, such as 153Sm and 177Lu, might easily …
radiolanthanides that have been used for therapy, such as 153Sm and 177Lu, might easily …
Dosimetry of yttrium-labelled radiopharmaceuticals for internal therapy: 86Y or 90Y imaging?
S Walrand, GD Flux, MW Konijnenberg… - European journal of …, 2011 - Springer
This paper reviews issues concerning 86 Y positron emission tomography (PET), 90 Y PET
and 90 Y bremsstrahlung imaging. Specific methods and corrections developed for …
and 90 Y bremsstrahlung imaging. Specific methods and corrections developed for …
64Cu-intraperitoneal radioimmunotherapy: A novel approach for adjuvant treatment in a clinically relevant preclinical model of pancreatic cancer
Y Yoshii, H Matsumoto, M Yoshimoto… - Journal of Nuclear …, 2019 - Soc Nuclear Med
Pancreatic cancer (PC) has a very poor prognosis. Surgery is the primary treatment for
patients with resectable PC; however, local recurrence, hepatic metastasis, and peritoneal …
patients with resectable PC; however, local recurrence, hepatic metastasis, and peritoneal …
[HTML][HTML] Single-dose anti-CD138 radioimmunotherapy: bismuth-213 is more efficient than lutetium-177 for treatment of multiple myeloma in a preclinical model
N Fichou, S Gouard, C Maurel, J Barbet, L Ferrer… - Frontiers in …, 2015 - frontiersin.org
Objectives Radioimmunotherapy (RIT) has emerged as a potential treatment option for
multiple myeloma (MM). In humans, a dosimetry study recently showed the relevance of RIT …
multiple myeloma (MM). In humans, a dosimetry study recently showed the relevance of RIT …
In vivo Evaluation of 177Lu- and 67/64Cu-Labeled Recombinant Fragments of Antibody chCE7 for Radioimmunotherapy and PET Imaging of L1-CAM-Positive …
J Grünberg, I Novak-Hofer, M Honer… - Clinical Cancer …, 2005 - AACR
Purpose: The L1 cell adhesion protein is overexpressed in tumors, such as neuroblastomas,
renal cell carcinomas, ovarian carcinomas, and endometrial carcinomas, and represents a …
renal cell carcinomas, ovarian carcinomas, and endometrial carcinomas, and represents a …
Cross-fire doses from β-emitting radionuclides in targeted radiotherapy. A theoretical study based on experimentally measured tumor characteristics
SA Enger, T Hartman, J Carlsson… - Physics in Medicine & …, 2008 - iopscience.iop.org
A mathematical model based upon histological findings of cell cluster distributions in primary
breast cancers and lymph node metastases was developed. The model is unique because it …
breast cancers and lymph node metastases was developed. The model is unique because it …