[HTML][HTML] Quantification of brain oxygen extraction and metabolism with [15O]-gas PET: a technical review in the era of PET/MRI

AP Fan, H An, F Moradi, J Rosenberg, Y Ishii, T Nariai… - Neuroimage, 2020 - Elsevier
Oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO 2) are
key cerebral physiological parameters to identify at-risk cerebrovascular patients and …

BOLD signal physiology: models and applications

CJ Gauthier, AP Fan - Neuroimage, 2019 - Elsevier
The BOLD contrast mechanism has a complex relationship with functional brain activity,
oxygen metabolism, and neurovascular factors. Accurate interpretation of the BOLD signal …

MRI estimation of global brain oxygen consumption rate

V Jain, MC Langham… - Journal of Cerebral Blood …, 2010 - journals.sagepub.com
Measuring the global cerebral metabolic rate of oxygen (CMRO 2) is a valuable tool for
assessing brain vitality and function. Measurement of blood oxygen saturation (HbO 2) and …

15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat

O Muzik, TJ Mangner, WR Leonard… - Journal of Nuclear …, 2013 - Soc Nuclear Med
Although it has been believed that brown adipose tissue (BAT) depots disappear shortly
after the perinatal period in humans, PET imaging using the glucose analog 18F-FDG has …

Quantitative oxygenation venography from MRI phase

AP Fan, B Bilgic, L Gagnon, T Witzel… - Magnetic resonance …, 2014 - Wiley Online Library
Purpose To demonstrate acquisition and processing methods for quantitative oxygenation
venograms that map in vivo oxygen saturation (SvO2) along cerebral venous vasculature …

Noninvasive quantification of whole‐brain cerebral metabolic rate of oxygen (CMRO2) by MRI

F Xu, Y Ge, H Lu - Magnetic Resonance in Medicine: An Official …, 2009 - Wiley Online Library
Cerebral metabolic rate of oxygen (CMRO2) is an important marker for brain function and
brain health. Existing techniques for quantification of CMRO2 with positron emission …

[HTML][HTML] Assessment of oxidative metabolism in brown fat using PET imaging

O Muzik, TJ Mangner, JG Granneman - Frontiers in endocrinology, 2012 - frontiersin.org
Objective: Although it has been believed that brown adipose tissue (BAT) depots disappear
shortly after the perinatal period in humans, positron emission tomography (PET) imaging …

Age dependence of hemodynamic response characteristics in human functional magnetic resonance imaging

CJ Gauthier, C Madjar, L Desjardins-Crépeau… - Neurobiology of …, 2013 - Elsevier
Functional magnetic resonance imaging (fMRI) studies of cognitive aging have generally
compared the amplitude and extent of blood oxygen level-dependent (BOLD) signal …

Phase‐based regional oxygen metabolism (PROM) using MRI

AP Fan, T Benner, DS Bolar, BR Rosen… - Magnetic resonance …, 2012 - Wiley Online Library
Venous oxygen saturation (Yv) in cerebral veins and the cerebral metabolic rate of oxygen
(CMRO2) are important indicators for brain function and disease. Although MRI has been …

How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen‐dependent …

HM Swartz, AB Flood, PE Schaner… - Physiological …, 2020 - Wiley Online Library
It is well understood that the level of molecular oxygen (O2) in tissue is a very important
factor impacting both physiology and pathological processes as well as responsiveness to …