Various biomarkers are available to support the diagnosis of neurodegenerative diseases in
clinical and research settings. Among the molecular imaging biomarkers, amyloid-PET …

With the increasing life expectancy in developed countries, the incidence of Alzheimer's
disease (AD) and thus its socioeconomic impact are growing. Increasing knowledge over …

The demographics of aging suggest a great need for the early diagnosis of dementia and
the development of preventive strategies. Neuropathology and structural MRI studies have …

Abstract Purpose of Review: This article discusses the recent advances in the diagnosis and
treatment of Alzheimer disease (AD). Recent Findings: In recent years, significant advances …

Alzheimer's disease (AD) is a progressive age-related neurodegenerative disease. At the
time of clinical manifestation of dementia, significant irreversible brain damage is already …

β-amyloid plaques (Aβ plaques) in the brain, containing predominantly fibrillary Aβ peptide
aggregates, represent a defining pathologic feature of Alzheimer disease (AD). Imaging …

Spatial navigation is a complex cognitive skill that is necessary for everyday functioning in
the environment. However, navigational skills are not typically measured in most test …

The aim of the present study is to compare brain atrophy with hypometabolism as preclinical
markers of Alzheimer's disease (AD) by studying presymptomatic individuals from families …

Age-related declines in spatial navigation are well-known in human and non-human
species. Studies in non-human species suggest that alteration in hippocampal and other …

Background Plasma glial fibrillary acidic protein (GFAP) has emerged as a promising
biomarker in neurological disorders, but further evidence is required in relation to its …