Pd-l1-targeted radionuclide therapy combined with αpd-l1 antibody immunotherapy synergistically improves the antitumor effect

X Wen, X Zeng, X Cheng, X Zeng, J Liu… - Molecular …, 2022 - ACS Publications
Immune checkpoint blockers (ICBs) targeting programmed death receptor 1 (PD-1) ligand 1
(PD-L1) for immunotherapy have radically reformed oncology. It is of great significance to …

Differential tumor cell targeting of anti-HER2 (HerceptinŽ) and anti-CD20 (MabtheraŽ) coupled nanoparticles

A Cirstoiu-Hapca, L Bossy-Nobs, F Buchegger… - International journal of …, 2007 - Elsevier
Two types of antibody-labeled nanoparticles (mAb-NPs) were prepared with the aim to
achieve specific tumor targeting. Anti-HER2 and anti-CD20 monoclonal antibodies (mAb) …

Porous hollow palladium nanoplatform for imaging-guided trimodal chemo-, photothermal-, and radiotherapy

M Song, N Liu, L He, G Liu, D Ling, X Su, X Sun - Nano Research, 2018 - Springer
Cancer is one of the major causes of human death. There are many types of cancer
treatment including surgery, chemotherapy, radiotherapy, and photothermal therapy …

Nanomedicines for active targeting: physico-chemical characterization of paclitaxel-loaded anti-HER2 immunonanoparticles and in vitro functional studies on target …

A Cirstoiu-Hapca, F Buchegger, L Bossy… - European Journal of …, 2009 - Elsevier
Paclitaxel (Tx)-loaded anti-HER2 immunonanoparticles (NPs-Tx-HER) were prepared by the
covalent coupling of humanized monoclonal anti-HER2 antibodies (trastuzumab …

[HTML][HTML] 99mTc-labeled Rituximab for Imaging B Lymphocyte Infiltration in Inflammatory Autoimmune Disease Patients

G Malviya, KL Anzola, E Podesta, B Lagana… - Molecular imaging and …, 2012 - Springer
Purpose The rationale of the present study was to radiolabel rituximab with 99m-technetium
and to image B lymphocytes infiltration in the affected tissues of patients with chronic …

Regional Radiochemotherapy Using In Situ Hydrogel

A Azhdarinia, DJ Yang, DF Yu, R Mendez, C Oh… - Pharmaceutical …, 2005 - Springer
Purpose. To evaluate the feasibility of regional radiochemotherapy of mammary tumors
using in situ hydrogel loaded with cisplatin (CDDP) and rhenium-188 (188 Re). Methods …

Preparation and preclinical evaluation of 131I‐trastuzumab for breast cancer

M Kameswaran, V Gota, R Ambade… - Journal of Labelled …, 2017 - Wiley Online Library
Trastuzumab that targets the human epidermal growth factor receptor type 2 (HER2) is
known to benefit patients with HER2+ metastatic breast cancer. The objective was to explore …

131I-Nimotuzumab–A potential radioimmunotherapeutic agent in treatment of tumors expressing EGFR

M Kameswaran, G Samuel, HD Sarma… - Applied Radiation and …, 2015 - Elsevier
The anti-EGFR antibody Nimotuzumab was radioiodinated with I-131 by Chloramine T and
Iodogen methods. The 131 I-Nimotuzumab was purified and characterized by HPLC …

[HTML][HTML] Long-term complete responses after 131I-tositumomab therapy for relapsed or refractory indolent non-Hodgkin's lymphoma

F Buchegger, C Antonescu, AB Delaloye, C Helg… - British journal of …, 2006 - nature.com
We present the long-term results of 18 chemotherapy relapsed indolent (N= 12) or
transformed (N= 6) NHL patients of a phase II anti-CD20 131 I-tositumomab (BexxarŽ) …

Efficacy of nimotuzumab (hR3) conjugated with 131I or 90Y in laryngeal carcinoma xenograft mouse model

TT Nguyen, AS Ho, TKG Nguyen… - … Journal of Radiation …, 2021 - Taylor & Francis
Purpose The humanized monoclonal antibody hR3, both alone and in combination with
other chemotherapeutic agents and radiotherapy, can be used to treat head and neck …