[18F]FLT-PET in oncology: current status and opportunities

LB Been, AJH Suurmeijer, DCP Cobben… - European journal of …, 2004 - Springer
Abstract In recent years,[18 F]-fluoro-3′-deoxy-3′-L-fluorothymidine ([18 F] FLT) has been
developed as a proliferation tracer. Imaging and measurement of proliferation with PET …

Imaging of cell proliferation: status and prospects

JR Bading, AF Shields - Journal of Nuclear Medicine, 2008 - Soc Nuclear Med
Increased cellular proliferation is an integral part of the cancer phenotype. Several in vitro
assays have been developed to measure the rate of tumor growth, but these require …

PET in the management of locally advanced and metastatic NSCLC

W Grootjans, LF de Geus-Oei, EGC Troost… - Nature reviews Clinical …, 2015 - nature.com
Despite considerable improvements in the treatment options for advanced-stage non-small-
cell lung cancer (NSCLC), disease-specific survival remains poor. With the aim of improving …

PET evaluation of lung cancer

T Bunyaviroch, RE Coleman - Journal of nuclear medicine, 2006 - Soc Nuclear Med
In the last hundred years, lung cancer has risen from a reportable disease to the most
common cause of death from cancer in both men and women in developed countries (1) …

Correlation of 18F-FLT and 18F-FDG uptake on PET with Ki-67 immunohistochemistry in non-small cell lung cancer

Y Yamamoto, Y Nishiyama, S Ishikawa… - European journal of …, 2007 - Springer
Purpose The nucleoside analogue 3′-deoxy-3′-18 F-fluorothymidine (FLT) has recently
been introduced for imaging cell proliferation with positron emission tomography (PET). We …

FLT: measuring tumor cell proliferation in vivo with positron emission tomography and 3′-deoxy-3′-[18F] fluorothymidine

A Salskov, VS Tammisetti, J Grierson… - Seminars in nuclear …, 2007 - Elsevier
Positron emission tomography (PET) using the radiotracer 3′-deoxy-3′-[18F]
fluorothymidine (FLT) can image cellular proliferation in human cancers in vivo. FLT uptake …

[HTML][HTML] Relation between nodule size and 18F-FDG-PET SUV for malignant and benign pulmonary nodules.

M Khalaf, H Abdel-Nabi, J Baker, Y Shao… - Journal of hematology & …, 2008 - Springer
Abstract The most common semiquantitative method of evaluation of pulmonary lesions
using 18 F-FDG PET is FDG standardized uptake value (SUV). An SUV cutoff of 2.5 or …

Differential 18F-FDG and 18F-FLT uptake on serial PET/CT imaging before and during definitive chemoradiation for non–small cell lung cancer

SJ Everitt, DL Ball, RJ Hicks, J Callahan… - Journal of Nuclear …, 2014 - Soc Nuclear Med
We aimed to prospectively observe cellular metabolism and proliferation in patients with non–
small-cell lung cancer (NSCLC) during radical chemoradiation therapy using serial PET/CT …

Non-[18F] FDG PET in clinical oncology

AM Groves, T Win, SB Haim, PJ Ell - The lancet oncology, 2007 - thelancet.com
PET is an exquisitely sensitive molecular imaging technique using positron-emitting
radioisotopes coupled to specific ligands. Many biological targets of great interest can be …

18F-FLT PET in hematologic disorders: a novel technique to analyze the bone marrow compartment

A Agool, BW Schot, PL Jager… - Journal of Nuclear …, 2006 - Soc Nuclear Med
Few diagnostic procedures are available to determine the degree of bone marrow cellularity
and the numbers of cycling cells in patients with bone marrow disorders. Noninvasive …