Radiometals comprise many useful radioactive isotopes of various metallic elements. When
properly harnessed, these have valuable emission properties that can be used for …

Radiometals possess an exceptional breadth of decay properties and have been applied to
medicine with great success for several decades. The majority of current clinical use …

Metallodrugs offer potential for unique mechanisms of drug action based on the choice of
the metal, its oxidation state, the types and number of coordinated ligands and the …

The eradication of cancer remains a vexing problem despite recent advances in our
understanding of the molecular basis of neoplasia. One therapeutic approach that has …

Among all existing radionuclides, only a few are of interest for therapeutic applications and
more specifically for targeted alpha therapy (TAT). From this selection, actinium-225 …

The potential of α-particle emitters to treat cancer has been recognized since the early
1900s. Advances in the targeted delivery of radionuclides and radionuclide conjugation …

The α-emitting radionuclide actinium-225 possesses nuclear properties that are highly
promising for use in targeted α therapy (TAT), a therapeutic strategy that employs α particle …

This review presents an overview of the successes and challenges currently faced in alpha
radionuclide therapy. Alpha particles have an advantage in killing tumour cells as compared …

Alpha-emitters are radionuclides that decay through the emission of high linear energy
transfer α-particles and possess favorable pharmacologic profiles for cancer treatment …

The effectiveness of targeted α-therapy (TAT) can be explained by the properties of α-
particles. Alpha particles are helium nuclei and are~ 8,000 times larger than β−-particles …