Perspectives on cancer therapy with radiolabeled monoclonal antibodies

RM Sharkey, DM Goldenberg - Journal of Nuclear Medicine, 2005 - Soc Nuclear Med
With the approval of 2 radiolabeled antibody products for the treatment of non-Hodgkin's
lymphoma (NHL), radioimmunotherapy (RIT) has finally come of age as a new therapeutic …

Results of Individual Patient Dosimetry in Peptide Receptor Radionuclide Therapy with 177Lu DOTA-TATE and 177Lu DOTA-NOC

C Wehrmann, S Senftleben, C Zachert… - Cancer biotherapy & …, 2007 - liebertpub.com
One of the few treatment options for inoperable neuroendocrine tumors (NET) is peptide
receptor radiotherapy with somatostatin analogs. In this study, we compared the dosimetric …

Review of clinical radioimmunotherapy

B Pohlman, J Sweetenham… - Expert review of …, 2006 - Taylor & Francis
Radioimmunotherapy involves a form of biologically targeted radiopharmaceutical treatment
in which a radioactive isotope (typically a short-range, high-energy β-emitter) is chemically …

The Bad Berka Dose Protocol: Comparative Results of Dosimetry in Peptide Receptor Radionuclide Therapy Using 177Lu-DOTATATE, 177Lu-DOTANOC, and 177 …

C Schuchardt, HR Kulkarni, V Prasad, C Zachert… - … , Gallium-68, and Other …, 2013 - Springer
Purpose: The objective of this study is to analyze the in vivo behavior of the 177 Lu-labeled
peptides DOTATATE, DOTANOC, and DOTATOC used for peptide receptor radionuclide …

Image quantification for radiation dose calculations—limitations and uncertainties

JM Pereira, MG Stabin, FRA Lima, M Guimarães… - Health …, 2010 - journals.lww.com
Radiation dose calculations in nuclear medicine depend on quantification of activity via
planar and/or tomographic imaging methods. However, both methods have inherent …

Comparison of conventional, model-based quantitative planar, and quantitative SPECT image processing methods for organ activity estimation using In-111 agents

B He, EC Frey - Physics in Medicine & Biology, 2006 - iopscience.iop.org
Accurate quantification of organ radionuclide uptake is important for patient-specific
dosimetry. The quantitative accuracy from conventional conjugate view methods is limited by …

Evaluation of quantitative imaging methods for organ activity and residence time estimation using a population of phantoms having realistic variations in anatomy and …

B He, Y Du, WP Segars, RL Wahl, G Sgouros… - Medical …, 2009 - Wiley Online Library
Estimating organ residence times is an essential part of patient‐specific dosimetry for
radioimmunotherapy (RIT). Quantitative imaging methods for RIT are often evaluated using …

Effects of shortened acquisition time on accuracy and precision of quantitative estimates of organ activity a

B He, EC Frey - Medical physics, 2010 - Wiley Online Library
Purpose: Quantitative estimation ofin vivo organ uptake is an essential part of treatment
planning for targeted radionuclide therapy. This usually involves the use of planar or SPECT …

RADAR commentary: evolution and current status of dosimetry in nuclear medicine

MG Stabin, RM Sharkey, JA Siegel - Journal of Nuclear Medicine, 2011 - Soc Nuclear Med
There is a long history of absorbed dose calculations being performed to evaluate the risks
involved in the application of radiopharmaceuticals to medical studies. In the 1940s …

Dual-modality imaging: more than the sum of its components

BH Hasegawa, H Zaidi - Quantitative analysis in nuclear medicine imaging, 2006 - Springer
The field of diagnostic radiology encompasses a wealth of imaging techniques that now are
essential for evaluating and managing patients who need medical care. Traditional imaging …