Airway neutrophilia is a common feature of many chronic inflammatory lung diseases and is
associated with disease progression, often regardless of the initiating cause. Neutrophils …

IDIOPATHIC PULMONARY FIBROSIS (IPF) is a progressive and lethal pulmonary fibrotic
lung disease. The diagnostic histological changes are called usual interstitial pneumonia …

Liver fibrosis is a serious, life-threatening disease with high morbidity and mortality that
result from diverse causes. Liver biopsy, considered the “gold standard” to diagnose, grade …

Rationale: Neutrophilic inflammation is understood to be of pathogenetic importance in
chronic obstructive pulmonary disease (COPD) and may be quantified using 18 …

Neutrophils have been implicated in the pathogenesis of alpha-1 antitrypsin deficiency
(AATD) since the first descriptions of the disease. Neutrophil proteinases can cause all lung …

18F-FDG positron emission tomographic (PET) scanning is a major imaging tool widely
used to investigate lung function and lung disease. Tomographic imaging of drug delivered …

Purpose Idiopathic pulmonary fibrosis (IPF) is a lethal lung disease for which no single
diagnostic modality is able to evaluate the activity of the disease process. Cis-4-18 F-fluoro-l …

Proline and hydroxyproline represent major constituents of mammalian structural proteins,
especially of collagen. An efficient radiosynthesis of the 18F-labeled proline derivatives cis …

This article reviews the potential use of positron emission tomography (PET), alone and in
combination with computed tomography, for evaluating the severity of disease in cystic …

Tumor imaging with cis-4-[18F] fluoro-L-proline (cis-FPro) was compared to that of L-[3H]
proline and L-[3H] methionine in F98 rat gliomas by dual-tracer autoradiography. All tracers …