Ischemic stroke is a complex pathology characterized by a sequence of events that evolve
over time and space. It is the second leading cause of death and the main cause of adult …

Adenosine is a neuromodulator with several functions in the central nervous system (CNS),
such as inhibition of neuronal activity in many signaling pathways. Most of the sedating …

Abstract Adenosine A 1 receptors (A 1 ARs) are promising imaging biomarkers and targets
for the treatment of stroke. Nevertheless, the role of A 1 ARs on ischemic damage and its …

An important factor for successful translational stroke research is study quality. Low-quality
studies are at risk of biased results and effect overestimation, as has been intensely …

Ischemia, through modulation of adenosine receptors (ARs), may influence adenosine‐
mediated‐cellular responses. In the present study, we investigated the modulation of rat A2A …

Positron emission tomography (PET) is a nuclear medicine imaging technique that allows in
vivo imaging of regional receptor-binding capacity. Advances in radiotracer chemistry have …

Adenosine is an endogenous modulator of synaptic functions in the central nervous system.
To investigate the physiologic and pathologic roles of the adenosine receptors in the human …

Fully quantitative analysis of the adenosine A1 receptor (A1R) in the brain with 11C-MPDX
and positron emission tomography is reported. The kinetics is described using a two-tissue …

Purpose The aim of this study was to establish the procedures for 3D voxel-based statistical
analysis of 2-deoxy-2-[18 F] fluro-d-glucose-positron emission tomography (FDG-PET) …

Advances in radiotracer chemistry have resulted in the development of novel molecular
imaging probes for adenosine receptors (ARs). With the availability of these molecules, the …