[HTML][HTML] Tikhonov adaptively regularized gamma variate fitting to assess plasma clearance of inert renal markers

CA Wesolowski, RC Puetter, L Ling… - … of pharmacokinetics and …, 2010 - Springer
The Tk-GV model fits Gamma Variates (GV) to data by Tikhonov regularization (Tk) with
shrinkage constant, λ, chosen to minimize the relative error in plasma clearance, CL …

Reference standard analysis of multiple new and old plasma clearance models and renal clearance with special attention to measurement of reduced glomerular …

CA Wesolowski - Scandinavian Journal of Clinical and Laboratory …, 2023 - Taylor & Francis
Nine models were evaluated as candidate glomerular filtration rate (GFR) reference
standards in three datasets using [51Cr (EDTA)]–or [169Yb (DTPA)] 2− anions in 98 studies …

[HTML][HTML] Validation of Tikhonov adaptively regularized gamma variate fitting with 24-h plasma clearance in cirrhotic patients with ascites

CA Wesolowski, L Ling, E Xirouchakis… - European journal of …, 2011 - Springer
Purpose The aim was to compare late-time extrapolation of plasma clearance (CL) from
Tikhonov adaptively regularized gamma variate fitting (Tk-GV) and from mono-exponential …

GFR determination in adults with a single-sample iohexol plasma clearance method based on the mean sojourn time

M Gref, K Karp - Nephrology Dialysis Transplantation, 2007 - academic.oup.com
Background. Glomerular filtration rate is a key parameter in kidney disease. The
Radionuclides in Nephrourology Committee has recommended a single-sample method …

On renal insufficiency measurement and reference standards using the logarithm of a cumulative exponential and multiple other plasma and renal clearance models

CA Wesolowski - arXiv preprint arXiv:2303.14995, 2023 - arxiv.org
For current models and methods, glomerular filtration rates below 20 ml/min in adults
resulted in modelling concentration tails that were frequently unseen on linear-log plotting …

The effect of improved modelling of plasma clearance in paediatric patients with expanded body spaces on estimation of the glomerular filtration rate

AS Perkinson, CJ Evans, MT Burniston… - Physiological …, 2009 - iopscience.iop.org
The glomerular filtration rate (GFR) is used clinically to assess renal function. The most
accurate estimation technique is tracer clearance where deterministic compartment …

A Bayesian 3-compartment model for 99mTc-MAG3 clearance

CD Russell - Journal of Nuclear Medicine, 2003 - Soc Nuclear Med
Because recent reports have questioned the traditional 2-compartment model for calculating
tracer clearance after a single intravenous injection, a 3-compartment model was evaluated …

Метаболическая иммунокоррекция в лечении больных распространенным перитонитом

ПВ Сарап - 2005 - elibrary.ru
Объект исследования: 96 больных с распространенным гнойным перитонитом
(диффузным и разлитым), а также 26 практически здоровых человек. Цель работы …

[PDF][PDF] Computational patient models for simulation of dynamic gamma-camera imaging

G Brolin - portal.research.lu.se
Approximately 110 000 diagnostic and therapeutic nuclear medicine procedures are
performed at Swedish hospitals each year (2015 [1]). In most diagnostic and in some …

Application of physics and mathematics in clinical nuclear medicine

L Ling - 2013 - research.library.mun.ca
This PhD research project consisted of two parts. In the first part a new pharmacokinetic
model was introduced to improve the accuracy of kidney function estimation based on a …