Antibody–drug conjugates (ADCs) constitute a relatively new group of anticancer agents,
whose first appearance took place about two decades ago, but a renewed interest occurred …

Nanotechnology has considerable promise for the detection, staging and treatment of
cancer. Here, we outline one such promising application: the use of nanostructures with …

One major hurdle to the success of adoptive T-cell therapy is the identification of antigens
that permit effective targeting of tumors in the absence of toxicities to essential organs …

Aims The leucine‐rich repeat kinase 2 (LRRK 2) G2019S mutation is the most common
genetic cause of Parkinson's disease (PD). There is compelling evidence that PD is not only …

Guanylin, uroguanylin, and the bacterial heat-stable enterotoxin (ST) peptides comprise a
new family of cyclic guanosine 3′-5′ monophosphate (cGMP)-regulating agonists. The …

Adoptive T-cell therapy (ACT) is an emerging paradigm in which T cells are genetically
modified to target cancer-associated antigens and eradicate tumors. However, challenges …

Mitochondrial dysfunction and reactive oxygen species (ROS) accumulation within the
substantia nigra pars compacta (SNpc) are central drivers of dopaminergic (DA) neuron …

Background & Aims: Although progression to adenocarcinoma at the gastroesophageal
junction reflects exposure to acid and bile acids associated with reflux, mechanisms …

Enterotoxigenic Escherichia coli (ETEC) associated diarrhea is responsible for roughly half
a million deaths per year, the majority taking place in developing countries. The main agent …

Colorectal cancer (CRC) is one of the leading causes of cancer related-deaths. The risk of
development of CRC is complex and multifactorial, and includes disruption of homeostasis …