Molecular imaging has witnessed a tremendous change over the last decade. Growing
interest and emphasis are placed on this specialized technology represented by developing …

Tissue hypoxia results from an inadequate supply of oxygen (O 2) that compromises
biological functions. Structural and functional abnormalities of the tumour vasculature …

The present study compares the uptake of [18F] Fluoroazomycinarabinofuranoside
(18FAZA), a recently developed hypoxia tracer for PET imaging of tissue hypoxia, with an …

There is a need to measure tumor hypoxia in assessing the aggressiveness of tumor and
predicting the outcome of therapy. A number of invasive and noninvasive techniques have …

Solid tumors are often poorly vascularized, which impairs oxygen supply and drug delivery
to the cells. This often leads to genetic and translational adaptations that promote tumor …

Background and Purpose—Nitroimidazole imaging is a promising contender for noninvasive
in vivo mapping of brain hypoxia after stroke. However, there is a dearth of knowledge about …

In this issue of Clinical Cancer Research, Rajendran et al.(1) have assessed the value of
pretherapy fluoromisonidazole (FMISO) positron emission tomography (PET) imaging, an …

Cancer is a lethal disease, and its therapy should be tailed to individual patients by
functional imaging to optimize therapy strategies. Single-photon emission computed …

Hypoxia, a condition of insufficient oxygen availability to support metabolism, occurs when
the vascular supply is interrupted, as in stroke. The identification of the hypoxic and viable …

Affected tissues in a number of diseases, including cancer, stroke, cardiac infarction and
diabetes, develop focal tissue hypoxia during their progression. The presence of hypoxic …