Highlights•Tumor cells increase their metabolic rates as well as glucose uptake to maintain
amplified proliferation,•Consequently, tumor cells switch from mitochondrial oxidative …

This review describes the application of 2 nuclear imaging techniques for assessment of
hepatic function in the setting of liver surgery and transplantation. The biochemical and …

Abstract Background and Objective: Liver cirrhosis is characterized by a decrease in
functional hepatocytes, lowered circulating levels of plasma proteins and alterations in blood …

Conjugation of small interfering RNA (siRNA) to tris N-acetylgalactosamine [(GalNAc) 3] can
enable highly selective, potent, and durable knockdown of targeted proteins in the liver …

In order to achieve microscopic radical resection margins and thus better survival, surgical
treatment of hepatic tumors has become more aggressive in the last decades, resulting in an …

Background Postoperative liver failure remains a life-threatening complication. Preoperative
evaluation of liver function is essential in reducing the complications after hepatectomy …

The fenestrated sinusoidal endothelium ('liver sieve') and space of Disse in the healthy liver
do not impede the transfer of most substrates, including drugs and oxygen, from the …

Proprotein convertase subtilisin/kexin type 9 (PCSK9) regulates plasma low-density
lipoprotein cholesterol (LDL-C) levels by promoting the degradation of hepatic LDL …

The abundant cell surface asialoglycoprotein receptor (ASGPR) is a highly selective
receptor found on hepatocytes that potentially can be exploited as a selective shuttle for …

Background. The effect of age on functioning hepatocyte mass and liver blood flow was
examined using 99mTc-galactosyl-human serum albumin (GSA) liver scintigraphy in …