Chimeric antigen receptor T cell (CAR-T) therapy is a new and effective form of adoptive cell
therapy that is rapidly entering the mainstream for the treatment of CD19-positive …

Targeted therapies, such as radioimmunotherapy (RIT), present a promising treatment
option for the eradication of tumor lesions. RIT has shown promising results especially for …

Protein engineering relies on the selective capture of members of a protein library with
desired properties. Yeast surface display technology routinely enables as much as million …

The use of antibodies against tumor-associated cell surface antigens for the targeted
delivery of radionuclides was introduced> 20 years ago. Although encouraging results have …

There remains an urgent need for the noninvasive tracking of transfused chimeric antigen
receptor (CAR) T cells to determine their biodistribution, viability, expansion, and antitumor …

Over the past several years, investigators in this laboratory and elsewhere have been
studying tumor localization by pretargeting with streptavidin and biotin or with avidin and …

INTRODUCTION: In pretargeted radioimmunotherapy (PRIT), a bifunctional antibody is
administered and allowed to pre-localize to tumor cells. Subsequently, a chelated …

A major focus of current drug research is to improve drug targeting to internal target sites
such as to solid tumors or specific organs. The objective of drug targeting, especially for …

While 188Re has been used successfully in mice for tumor radiotherapy by MORF/cMORF
pretargeting, previous radiolabeling of the amine-derivatized cMORF with 90Y, a longer …

An antibody that binds rare earth complexes selectively could be used as a docking station
for a set of probe molecules, of particular interest for medical imaging and therapy. The rare …