Molecular radiotherapy (MRT) has demonstrated unique therapeutic advantages in the
treatment of an increasing number of cancers. As with other treatment modalities, there is …

Neuroblastoma, the most common extracranial solid tumor in children, is derived from neural
crest cells. Nearly half of patients present with metastatic disease and have a 5-year event …

Introduction The level of administered activity in radionuclide therapy is often limited by
haematological toxicity resulting from the absorbed dose delivered to the bone marrow. The …

Randomized Phase II Trial of MIBG Versus MIBG, Vincristine, and Irinotecan Versus MIBG
and Vorinostat for Patients With Relapsed or Refractory Neuroblastoma: A Report From …

Purpose To evaluate the safety and efficacy of high-dose [131 I] metaiodobenzylguanidine
([131 I] MIBG) in the treatment of malignant pheochromocytoma (PHEO) and paraganglioma …

Radiopharmaceutical therapy (RPT) is defined as the delivery of radioactive atoms to tumor-
associated targets. In RPT, imaging is built into the mode of treatment since the …

Meta-iodobenzylguanidine, or Iobenguane, is an aralkylguanidine resulting from the
combination of the benzyl group of bretylium and the guanidine group of guanethidine (an …

Purpose To evaluate the effect of disease sites and prior therapy on response and toxicity
after iodine-131-metaiodobenzylguanidine (131I-MIBG) treatment of patients with resistant …

The optimal use and effectiveness of 131 I-meta iodobenzylguanidine (131 I-mIBG)
molecular radiotherapy for neuroblastoma remain unclear despite extensive clinical …

The purpose of the EANM Dosimetry Committee Series on “Standard Operational
Procedures for Dosimetry”(SOP) is to provide advice to scientists and clinicians on how to …