Reproducibility of 11C-raclopride binding in the rat brain measured with the microPET R4: effects of scatter correction and tracer specific activity
DL Alexoff, P Vaska, D Marsteller… - Journal of Nuclear …, 2003 - Soc Nuclear Med
A new generation of commercial animal PET cameras may accelerate drug development by
streamlining preclinical testing in laboratory animals. However, little information on the …
streamlining preclinical testing in laboratory animals. However, little information on the …
Cyclosporine, a P-glycoprotein modulator, increases [18F]MPPF uptake in rat brain and peripheral tissues: microPET and ex vivo studies
G Laćan, A Plenevaux, DJ Rubins, BM Way… - European journal of …, 2008 - Springer
Purpose Pretreatment with cyclosporine, a P-glycoprotein (P-gp) modulator increases brain
uptake of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-[18 F] fluorobenzamido] …
uptake of 4-(2'-methoxyphenyl)-1-[2'-(N-2"-pyridinyl)-p-[18 F] fluorobenzamido] …
Statistical parametric maps of 18F-FDG PET and 3-D autoradiography in the rat brain: a cross-validation study
Purpose Although specific positron emission tomography (PET) scanners have been
developed for small animals, spatial resolution remains one of the most critical technical …
developed for small animals, spatial resolution remains one of the most critical technical …
Evaluation of the integrity of the dopamine system in a rodent model of Parkinson's disease: small animal positron emission tomography compared to behavioral …
Abstract Purpose In the 6-hydroxydopamine (6-OHDA) rat model of Parkinson's disease
(PD), it is important to determine lesion severity. This evaluation can be performed in vivo …
(PD), it is important to determine lesion severity. This evaluation can be performed in vivo …
Bilateral increase in striatal dopamine D2 receptor density in the 6-hydroxydopamine-lesioned rat: a serial in vivo investigation with small animal PET
S Nikolaus, R Larisch, M Beu, F Forutan… - European journal of …, 2003 - Springer
Unilateral destruction of the substantia nigra by local application of 6-hydroxydopamine (6-
OHDA) serves as an animal model for Parkinson's disease. In this study, the changes in …
OHDA) serves as an animal model for Parkinson's disease. In this study, the changes in …
Quantitation of dopamine transporter blockade by methylphenidate: first in vivo investigation using [123I]FP-CIT and a dedicated small animal SPECT
S Nikolaus, A Wirrwar, C Antke, S Arkian… - European journal of …, 2005 - Springer
Purpose The aim of this study was to investigate the feasibility of assessing dopamine
transporter binding after treatment with methylphenidate in the rat using a recently …
transporter binding after treatment with methylphenidate in the rat using a recently …
Quantitative in vitro phosphor imaging using [3H] and [18F] radioligands: the effects of chronic desipramine treatment on serotonin 5-HT2 receptors
EM Strome, S Jivan, DJ Doudet - Journal of neuroscience methods, 2005 - Elsevier
Traditionally, autoradiography of neuroreceptors is performed in vitro using tritiated ligands
and low sensitivity X-ray film, requiring long exposure times. In vivo imaging of …
and low sensitivity X-ray film, requiring long exposure times. In vivo imaging of …
Development of a simultaneous PET/microdialysis method to identify the optimal dose of 11C-raclopride for small animal imaging
WK Schiffer, DL Alexoff, C Shea, J Logan… - Journal of neuroscience …, 2005 - Elsevier
In the field of small animal positron emission tomography (PET), the assumptions underlying
human and primate kinetic models may not be sustained in rodents. That is, the threshold …
human and primate kinetic models may not be sustained in rodents. That is, the threshold …
Imaging of striatal dopamine transporters in rat brain with single pinhole SPECT and co-aligned MRI is highly reproducible
J Booij, K de Bruin, MML de Win, C Lavini… - Nuclear medicine and …, 2003 - Elsevier
A recently developed pinhole high-resolution SPECT system was used to measure striatal to
non-specific binding ratios in rats (n= 9), after injection of the dopamine transporter ligand …
non-specific binding ratios in rats (n= 9), after injection of the dopamine transporter ligand …
[123I]Iodobenzamide binding to the rat dopamine D2 receptor in competition with haloperidol and endogenous dopamine—an in vivo imaging study with a dedicated …
S Nikolaus, R Larisch, A Wirrwar… - European journal of …, 2005 - Springer
Purpose This study assessed [123 I] iodobenzamide binding to the rat dopamine D 2
receptor in competition with haloperidol and endogenous dopamine using a high-resolution …
receptor in competition with haloperidol and endogenous dopamine using a high-resolution …