Sympathetic nervous system activation in human heart failure: clinical implications of an updated model

JS Floras - Journal of the American College of cardiology, 2009 - jacc.org
Disturbances in cardiovascular neural regulation, influencing both disease course and
survival, progress as heart failure worsens. Heart failure due to left ventricular systolic …

The role of neuronal and extraneuronal plasma membrane transporters in the inactivation of peripheral catecholamines

G Eisenhofer - Pharmacology & therapeutics, 2001 - Elsevier
Catecholamines are translocated across plasma membranes by transporters that belong to
two large families with mainly neuronal or extraneuronal locations. In mammals, neuronal …

I-123 MIBG imaging and heart rate variability analysis to predict the need for an implantable cardioverter defibrillator

R Arora, KJ Ferrick, T Nakata, RC Kaplan… - Journal of Nuclear …, 2003 - Elsevier
Background. Iodine 123 metaiodobenzylguanidine (MIBG) imaging and heart rate variability
(HRV) analysis were compared in patients with an implantable cardioverter defibrillator …

Left ventricular assist device support normalizes left and right ventricular beta-adrenergic pathway properties

S Klotz, A Barbone, S Reiken, JW Holmes… - Journal of the American …, 2005 - jacc.org
Objectives: We hypothesized that some aspects of left ventricular assist device (LVAD)
reverse remodeling could be independent of hemodynamic factors and would primarily …

Cardiac applications of 123I-mIBG imaging

A Chirumamilla, MI Travin - Seminars in nuclear medicine, 2011 - Elsevier
Cardiac autonomic innervation plays a key role in maintaining hemodynamic and
electrophysiologic harmony. Cardiac sympathetic function is adversely altered in many …

Myocardial sympathetic innervation and long-term left ventricular mechanical unloading

SG Drakos, T Athanasoulis, KG Malliaras… - JACC: Cardiovascular …, 2010 - jacc.org
Objectives: The purpose of this study was to analyze the effects of left ventricular assist
devices (LVADs) on myocardial sympathetic innervation of the failing heart. Background …

Neuronal imaging using SPECT

S Yamashina, J Yamazaki - European journal of nuclear medicine and …, 2007 - Springer
Abstract Background 123 I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy is one
of only a few methods available for objective evaluation of cardiac sympathetic function at a …

Cardiac autonomic imaging with SPECT tracers

MI Travin - Journal of Nuclear Cardiology, 2013 - Elsevier
Radionuclide cardiac imaging has potential to assess underlying molecular,
electrophysiologic, and pathophysiologic processes of cardiac disease. An area of current …

Carvedilol improves left ventricular function in heart failure patients with idiopathic dilated cardiomyopathy and a wide range of sympathetic nervous system function …

MC Gerson, LL Craft, N McGuire, DP Suresh… - Journal of nuclear …, 2002 - Springer
Background Carvedilol treatment reduces the mortality rate in patients with congestive heart
failure. It is not known whether carvedilol treatment is effective in heart failure patients with …

123I-MIBG SPECT for evaluation of patients with heart failure

AC Dimitriu-Leen, AJHA Scholte… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Heart failure (HF) is characterized by activation of the sympathetic cardiac nerves. The
condition of cardiac sympathetic nerves can be evaluated by 123 I …