Pseudoprogression, radionecrosis, inflammation or true tumor progression? Challenges associated with glioblastoma response assessment in an evolving …

BM Ellingson, C Chung, WB Pope, JL Boxerman… - Journal of neuro …, 2017 - Springer
The wide variety of treatment options that exist for glioblastoma, including surgery, ionizing
radiation, anti-neoplastic chemotherapies, anti-angiogenic therapies, and active or passive …

Clinical applications of PET in brain tumors

W Chen - Journal of nuclear medicine, 2007 - Soc Nuclear Med
Malignant gliomas and metastatic tumors are the most common brain tumors. Neuroimaging
plays a significant role clinically. In low-grade tumors, neuroimaging is needed to evaluate …

Long-term risk of radionecrosis and imaging changes after stereotactic radiosurgery for brain metastases

ZA Kohutek, Y Yamada, TA Chan, CW Brennan… - Journal of neuro …, 2015 - Springer
Radionecrosis is a well-characterized effect of stereotactic radiosurgery (SRS) and is
occasionally associated with serious neurologic sequelae. Here, we investigated the …

Segmentation of tumor and edema along with healthy tissues of brain using wavelets and neural networks

A Demirhan, M Törü, I Güler - IEEE journal of biomedical and …, 2014 - ieeexplore.ieee.org
Robust brain magnetic resonance (MR) segmentation algorithms are critical to analyze
tissues and diagnose tumor and edema in a quantitative way. In this study, we present a …

Diffusion-weighted imaging in the follow-up of treated high-grade gliomas: tumor recurrence versus radiation injury

PA Hein, CJ Eskey, JF Dunn… - American Journal of …, 2004 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Diffusion-weighted (DW) MR imaging is a means to
characterize and differentiate morphologic features, including edema, necrosis, and tumor …

Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods

R Ahmed, MJ Oborski, M Hwang… - Cancer management …, 2014 - Taylor & Francis
Malignant gliomas consist of glioblastomas, anaplastic astrocytomas, anaplastic
oligodendrogliomas and anaplastic oligoastrocytomas, and some less common tumors such …

Molecular imaging of gliomas with PET: opportunities and limitations

C la Fougere, B Suchorska, P Bartenstein… - Neuro …, 2011 - academic.oup.com
Neuroimaging enables the noninvasive evaluation of glioma and is considered to be one of
the key factors for individualized therapy and patient management, since accurate diagnosis …

Postradiation imaging changes in the CNS: how can we differentiate between treatment effect and disease progression?

AJ Walker, J Ruzevick, AA Malayeri, D Rigamonti… - Future …, 2014 - Future Medicine
A familiar challenge for neuroradiologists and neuro-oncologists is differentiating between
radiation treatment effect and disease progression in the CNS. Both entities are …

Disease progression or pseudoprogression after concomitant radiochemotherapy treatment: pitfalls in neurooncology

AA Brandes, A Tosoni, F Spagnolli, G Frezza… - Neuro …, 2008 - academic.oup.com
Although radionecrosis has been exhaustively described in depth in the neurooncological
literature, its diagnosis is still a challenging issue because its radiological pattern is …

Diffusion-weighted imaging of radiation-induced brain injury for differentiation from tumor recurrence

C Asao, Y Korogi, M Kitajima, T Hirai… - American Journal …, 2005 - Am Soc Neuroradiology
BACKGROUND AND PURPOSE: Differentiation between tumor recurrence and treatment-
related brain injury is often difficult with conventional MRI. We hypothesized that the diffusion …