[HTML][HTML] Targeting tumor hypoxia and mitochondrial metabolism with anti-parasitic drugs to improve radiation response in high-grade gliomas
Abstract High-grade gliomas (HGGs), including glioblastoma and diffuse intrinsic pontine
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …
glioma, are amongst the most fatal brain tumors. These tumors are associated with a dismal …
Conjugated photosensitizers for imaging and PDT in cancer research
JCS Simões, S Sarpaki… - Journal of medicinal …, 2020 - ACS Publications
Early cancer detection and perfect understanding of the disease are imperative toward
efficient treatments. It is straightforward that, for choosing a specific cancer treatment …
efficient treatments. It is straightforward that, for choosing a specific cancer treatment …
[HTML][HTML] PET radiopharmaceuticals for imaging of tumor hypoxia: a review of the evidence
Hypoxia is a pathological condition arising in living tissues when oxygen supply does not
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …
adequately cover the cellular metabolic demand. Detection of this phenomenon in tumors is …
Molecular imaging of gliomas with PET: opportunities and limitations
C la Fougere, B Suchorska, P Bartenstein… - Neuro …, 2011 - academic.oup.com
Neuroimaging enables the noninvasive evaluation of glioma and is considered to be one of
the key factors for individualized therapy and patient management, since accurate diagnosis …
the key factors for individualized therapy and patient management, since accurate diagnosis …
Correlation of hypoxic cell fraction and angiogenesis with glucose metabolic rate in gliomas using 18F-fluoromisonidazole, 18F-FDG PET, and immunohistochemical …
LM Cher, C Murone, N Lawrentschuk… - Journal of Nuclear …, 2006 - Soc Nuclear Med
PET offers a noninvasive means to assess neoplasms, in view of its sensitivity and accuracy
in staging tumors and potentially in monitoring treatment response. The aim of this study was …
in staging tumors and potentially in monitoring treatment response. The aim of this study was …
Prospective feasibility trial of radiotherapy target definition for head and neck cancer using 3-dimensional PET and CT imaging
C Scarfone, WC Lavely, AJ Cmelak… - Journal of Nuclear …, 2004 - Soc Nuclear Med
The aim of this investigation was to evaluate the influence and accuracy of 18F-FDG PET in
target volume definition as a complementary modality to CT for patients with head and neck …
target volume definition as a complementary modality to CT for patients with head and neck …
Hypoxia imaging in gliomas with 18F-fluoromisonidazole PET: toward clinical translation
C Bell, N Dowson, M Fay, P Thomas, S Puttick… - Seminars in nuclear …, 2015 - Elsevier
There is significant interest in the development of improved image-guided therapy for neuro-
oncology applications. Glioblastomas (GBM) in particular present a considerable challenge …
oncology applications. Glioblastomas (GBM) in particular present a considerable challenge …
Drug elimination kinetics following subconjunctival injection using dynamic contrast-enhanced magnetic resonance imaging
SH Kim, KG Csaky, NS Wang, RJ Lutz - Pharmaceutical research, 2008 - Springer
Purpose To determine the elimination rates of subconjunctivally injected model drugs using
dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods Gadolinium …
dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). Methods Gadolinium …
Prognostic evaluation of disease outcome in solid tumors investigated with 64Cu-ATSM PET/CT
E Lopci, I Grassi, D Rubello, PM Colletti… - Clinical nuclear …, 2016 - journals.lww.com
Results All patients showed a moderately to highly increased uptake of 64 Cu-ATSM in
tumor lesions, with a mean SUV max of 5.2 (range, 1.9–8.3) and mean SUV ratio of 4.4 …
tumor lesions, with a mean SUV max of 5.2 (range, 1.9–8.3) and mean SUV ratio of 4.4 …
Positron emission tomography in lung cancer
IH Shon, MJ O'doherty, MN Maisey - Seminars in nuclear medicine, 2002 - Elsevier
Carcinoma of the lung is one of the most frequent malignancies and a major cause of
mortality. The use of positron emission tomography (PET) has been extensively investigated …
mortality. The use of positron emission tomography (PET) has been extensively investigated …