Regional distribution and kinetics of inhaled pharmaceuticals.

MS Berridge, Z Lee, DL Heald - Current pharmaceutical design, 2000 - ingentaconnect.com
Drug biodistribution is often secondary to drug action. However, drugs that have a topical
action and are deposited into the airway by inhalation are dependent on effective deposition …

Preparation of super soft granules from nanosized ceramic powders by spray freezing

T Moritz, A Nagy - Journal of Nanoparticle Research, 2002 - Springer
Owing to their extremely high specific surfaces and their high surface-to-volume ratios
nanosized ceramic powders show a strong tendency to agglomeration and poor flowability …

Surfactant protein B labelled with [99mTc (CO) 3 (H2O) 3]+ retains biological activity in vitro

A Amann, C Decristoforo, I Ott, M Wenger… - Nuclear medicine and …, 2001 - Elsevier
Labelling of the hydrophobic surfactant protein B (SP-B) under non-reducing conditions was
achieved with [99mTc (CO) 3 (H2O) 3]+ prepared according to Alberto et al.(JACS, 1998) …

A Noninvasive [99mTc]DTPA SPECT/CT Imaging Methodology as a Measure of Lung Permeability in a Guinea Pig Model of COPD

Y Wu, CJ Kotzer, S Makrogiannis, GA Logan… - Molecular imaging and …, 2011 - Springer
Purpose The purposes of this study are (1) to develop an efficient aerosol inhalation system
for the delivery of [99m Tc] DTPA aerosol into guinea pig airways with high uniformity for …

Imaging studies of biodistribution and kinetics in drug development

MS Berridge, DL Heald, Z Lee - Drug development research, 2003 - Wiley Online Library
Although the intravenous route of administration is rarely used for drugs, it is by far the most
common route for PET and SPECT radiotracers. This article discusses the use of planar and …

99mTc-ENS ventilation scintigraphy: preliminary study in human volunteers

G Calmanovici, J Boccio, C Goldman, A Hager… - Nuclear medicine and …, 2000 - Elsevier
Exogenous natural surfactant (ENS) labeled with 99mTc (99mTc-ENS, 900–1110 MBq), a
new radiopharmaceutical for ventilation scintigraphy, was nebulized during 3 min to five …

[HTML][HTML] Role of the Lung Surfactant in the Treatment of Sars-Cov-2 Infection

B Riccardi, T De Paoli, S Resta - … of Biotechnology & …, 2020 - onlinescientificresearch.com
The spread of SARS-CoV2 has been progressing continuously for over eight months.
Numerous treatments have been proposed, and many have shown efficacy and ability to …

[PDF][PDF] Journal of Biotechnology & Bioinformatics Research

B Riccardi, S Resta, R Fabbroni - researchgate.net
In this work we analyze the current interpretations based on the studies of Nutrigenomic and
Microbiomics, according to which, at the base of many pathological and dysmetabolic …

Evaluation of different formulations to label exogenous natural surfactant labeled with (99m-Tc-ENS): stability and toxicity studies

G Calmanovic, R Caro, C Goldman… - Rev. med. nucl …, 2003 - pesquisa.bvsalud.org
El surfactante natural exógeno (ENS) marcado con 99mTc (99mTc-ENS) es un nuevo
agente ventilatorio para la centellografía aérea pulmonar. Con el fin de elegir una …

Scintigraphic Assessment of the Regional Distribution and Kinetics of Pharmaceuticals

MS Berridge, Z Lee - Journal of Pharmacy Practice, 2001 - journals.sagepub.com
A lesser known use of imaging studies in drug development is to determine the patterns of
deposition, biodistribution, and regional kinetics of drugs in the body. This kind of study is of …