Diabetes: models, signals, and control

C Cobelli, C Dalla Man, G Sparacino… - IEEE reviews in …, 2009 - ieeexplore.ieee.org
The control of diabetes is an interdisciplinary endeavor, which includes a significant
biomedical engineering component, with traditions of success beginning in the early 1960s …

Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans

KA Virtanen, P Lönnroth, R Parkkola… - The Journal of …, 2002 - academic.oup.com
To elucidate the role of adipose tissue glucose uptake in whole-body metabolism, sc and
visceral adipose tissue glucose uptake and perfusion were measured in 10 nonobese and …

Obesity is associated with increased basal and postprandial β-cell insulin secretion even in the absence of insulin resistance

S van Vliet, HCE Koh, BW Patterson, M Yoshino… - Diabetes, 2020 - Am Diabetes Assoc
We tested the hypothesis that obesity, independent of insulin resistance, is associated with
increased insulin secretion. We compared insulin kinetics before and after glucose ingestion …

Independent association of type 2 diabetes and coronary artery disease with myocardial insulin resistance

P Iozzo, P Chareonthaitawee, D Dutka… - Diabetes, 2002 - Am Diabetes Assoc
Clustering of classical cardiovascular risk factors is insufficient to account for the excess
coronary artery disease (CAD) of patients with diabetes, and chronic hyperglycemia and …

Rosiglitazone but not metformin enhances insulin-and exercise-stimulated skeletal muscle glucose uptake in patients with newly diagnosed type 2 diabetes

K Hallsten, KA Virtanen, F Lonnqvist, H Sipilä… - Diabetes, 2002 - Am Diabetes Assoc
Rosiglitazone, a thiazolidinedione, enhances peripheral insulin sensitivity in patients with
type 2 diabetes. Because the synergic action of insulin and exercise has been shown to be …

Myocardial and skeletal muscle glucose uptake during exercise in humans

J Kemppainen, T Fujimoto, KK Kalliokoski… - The Journal of …, 2002 - Wiley Online Library
The purpose of this study was to investigate the effects of exercise on myocardial glucose
uptake and whether the pattern of glucose uptake is the same as in skeletal muscle. Glucose …

Minimal and maximal models to quantitate glucose metabolism: tools to measure, to simulate and to run in silico clinical trials

C Cobelli, C Dalla Man - Journal of diabetes science and …, 2022 - journals.sagepub.com
Several models have been proposed to describe the glucose system at whole-body,
organ/tissue and cellular level, designed to measure non-accessible parameters (minimal …

Human adipose tissue glucose uptake determined using [18F]-fluoro-deoxy-glucose ([18F] FDG) and PET in combination with microdialysis

KA Virtanen, P Peltoniemi, P Marjamäki, M Asola… - Diabetologia, 2001 - Springer
Aims/hypothesis: To determine the lumped constant (LC), which accounts for the differences
in the transport and phosphorylation between [18 F]-2-fluoro-2-deoxy-d-glucose ([18 F] FDG) …

Obesity risk is associated with brain glucose uptake and insulin resistance

L Pekkarinen, T Kantonen, E Rebelos… - European Journal of …, 2022 - academic.oup.com
Objective To investigate whether alterations in brain glucose uptake (BGU), insulin action in
the brain–liver axis and whole-body insulin sensitivity occur in young adults in pre-obese …

Lumped constant for [18F]fluorodeoxyglucose in skeletal muscles of obese and nonobese humans

P Peltoniemi, P Lönnroth, H Laine… - American Journal …, 2000 - journals.physiology.org
Quantitative 2-[18F] fluoro-2-deoxy-d-glucose ([18F] FDG) positron emission tomography
(PET) has been widely used to calculate glucose utilization in skeletal muscle. FDG-PET …