Rationales, evidence, and design considerations for fractionated radioimmunotherapy
GL DeNardo, J Schlom, DJ Buchsbaum… - … Journal of the …, 2002 - Wiley Online Library
Although fractionation can be used in a discrete radiobiologic sense, herein it is generally
used in the broader context of administration of multiple, rather than single, doses of …
used in the broader context of administration of multiple, rather than single, doses of …
The radiation biology of radioimmunotherapy
KL Dixon - Nuclear medicine communications, 2003 - journals.lww.com
The treatment of cancer is a wide and varied field, encompassing many methods and
modalities. Radioimmunotherapy is a technique which utilizes the ablative properties of …
modalities. Radioimmunotherapy is a technique which utilizes the ablative properties of …
Pharmacokinetic/pharmacodynamic modeling of IVIG effects in a murine model of immune thrombocytopenia
R Deng, JP Balthasar - Journal of pharmaceutical sciences, 2007 - Elsevier
IVIG may achieve its beneficial effects in immune thrombocytopenia (ITP) patients via
several mechanisms; however, little is known of the relative importance of various …
several mechanisms; however, little is known of the relative importance of various …
Model prediction of treatment planning for dose‐fractionated radioimmunotherapy
S Shen, J Duan, RF Meredith… - … Journal of the …, 2002 - Wiley Online Library
BACKGROUND Clinical trials of radioimmunotherapy (RIT) often use dose fractionation to
reduce marrow toxicity. The dosing scheme can be optimized if marrow and tumor cell …
reduce marrow toxicity. The dosing scheme can be optimized if marrow and tumor cell …
Rhenium-188 and copper-67 radiopharmaceuticals for the treatment of bladder cancer.
M Frier - Mini Reviews in Medicinal Chemistry, 2004 - europepmc.org
The favourable nuclear properties of copper-67 and rhenium-188 for therapeutic application
are described, together with methods for the chemical synthesis of a number of derivatives …
are described, together with methods for the chemical synthesis of a number of derivatives …
Methods for determining absorbed dose information
The disclosure discusses methods for determining absorbed dose information. A
tomography imaging device generates an anatomy image relating to anatomy of a particular …
tomography imaging device generates an anatomy image relating to anatomy of a particular …
Planning time for peripheral blood stem cell infusion after high-dose targeted radionuclide therapy using dosimetry
S Shen, SJ DeNardo, CM Richman… - Journal of Nuclear …, 2005 - Soc Nuclear Med
Myelotoxicity can be ameliorated by peripheral blood stem cell (PBSC) infusion. Continuous
irradiation by radioactivity retained in the body after high-dose radioimmunotherapy can …
irradiation by radioactivity retained in the body after high-dose radioimmunotherapy can …
Method and system for administering radiopharmaceutical therapy (RPT)
G Sgouros, R Hobbs - US Patent 9,757,084, 2017 - Google Patents
(57) ABSTRACT A computerized system and method for determining an optimum amount of
radiopharmaceutical therapy (RPT) to administer, comprising: performing processing …
radiopharmaceutical therapy (RPT) to administer, comprising: performing processing …
Lymphocyte activation with localized pGL1-TNF-alpha gene therapy in a glioma model
DS Gridley, J Li, EH Kajioka, R Dutta-Roy, ML Andres… - Oncology, 2002 - karger.com
The major goal of this study was to evaluate the effects of tumor necrosis factor-α (TNF-α),
delivered as pGL1-TNF-α, on hematological variables, as well as C6 tumor growth in …
delivered as pGL1-TNF-α, on hematological variables, as well as C6 tumor growth in …
A compartmental model of mouse thrombopoiesis and erythropoiesis to predict bone marrow toxicity after internal irradiation
N Sas, J Rousseau, F Nguyen, E Bellec… - Journal of Nuclear …, 2014 - Soc Nuclear Med
In targeted radionuclide radiotherapy, the relationship between bone marrow (BM) toxicity
and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis …
and absorbed dose seems to be elusive. A compartmental model of mouse thrombopoiesis …