This review gives an insight into the beginnings of dopamine transporter (DAT) imaging in
the early 1990s, focussing on single photon emission tomography (SPECT). The …

Positron emission tomography (PET) is useful for noninvasive in vivo visualization of
disease-related receptors, for evaluation of receptor occupancy to determine an appropriate …

Abstract Knowledge of drug concentration-time profiles at the central nervous system (CNS)
target-site is critically important for rational development of CNS targeted drugs. Our aim was …

The development of drugs for central nervous system (CNS) disorders has encountered high
failure rates. In part, this has been due to the sole focus on blood-brain barrier permeability …

This article will review the capabilities and accomplishments of radiotracer imaging with
single photon emission computed tomography (SPECT) and positron emission tomography …

Considerable progress has been achieved over the past 15 years in uncovering the
biological basis of major psychiatric disorders. Since psychopharmacological treatment is …

Amisulpride appears to be an effective agent for treating positive or negative symptoms of
schizophrenia, depending on dose. The aim of this study was to assess striatal dopamine …

A crucial characteristic of antipsychotic medication is the occupancy of the dopamine (DA)
D2 receptor. We assessed striatal DA D2 receptor occupancy by olanzapine and risperidone …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by a
severe loss of the dopaminergic neurons in the substantia nigra pars compacta. In this study …

To evaluate the contribution of individual synaptic constituents, all available in vivo imaging
studies on schizophrenic patients were subjected to a retrospective analysis. For the pool of …