Peptide receptor therapies in neuroendocrine tumors

L Bodei, D Ferone, CM Grana, M Cremonesi… - Journal of …, 2009 - Springer
Neuroendocrine tumors (NETs) are relatively rare tumors, mainly originating from the
digestive system, able to produce bioactive amines and hormones. NETs tend to be slow …

[HTML][HTML] Benzamide derivative radiotracers targeting melanin for melanoma imaging and therapy: Preclinical/clinical development and combination with other …

J Rouanet, M Quintana, P Auzeloux, F Cachin… - Pharmacology & …, 2021 - Elsevier
Cutaneous melanoma arises from proliferating melanocytes, cells specialized in the
production of melanin. This property means melanin can be considered as a target for …

Dopamine D2 receptor binding before and after treatment of major depression measured by [123I] IBZM SPECT

A Klimke, R Larisch, A Janz, H Vosberg… - Psychiatry Research …, 1999 - Elsevier
Fifteen patients fulfilling DSM-IV criteria for major depression were investigated with the
specific dopamine D2 receptor antagonist [123I] iodobenzamide (IBZM). Two single photon …

PET and SPECT imaging of melanoma: the state of the art

W Wei, EB Ehlerding, X Lan, Q Luo, W Cai - European journal of nuclear …, 2018 - Springer
Melanoma represents the most aggressive form of skin cancer, and its incidence continues
to rise worldwide. 18 F–FDG PET imaging has transformed diagnostic nuclear medicine and …

Development of 18F-Labeled Picolinamide Probes for PET Imaging of Malignant Melanoma

H Liu, S Liu, Z Miao, Z Deng, B Shen… - Journal of medicinal …, 2013 - ACS Publications
Melanoma is an aggressive skin cancer with worldwide increasing incidence. Development
of positron emission tomography (PET) probes for early detection of melanoma is critical for …

High-contrast PET of melanoma using 18F-MEL050, a selective probe for melanin with predominantly renal clearance

D Denoyer, I Greguric, P Roselt, OC Neels… - Journal of Nuclear …, 2010 - Soc Nuclear Med
The aim of this study was to evaluate the novel probe 18F-6-fluoro-N-[2-(diethylamino) ethyl]
pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma …

Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52

W Mier, C Kratochwil, JC Hassel… - Journal of Nuclear …, 2014 - Soc Nuclear Med
The performance of cytotoxic drugs is defined by their selectivity of uptake and action in
tumor tissue. Recent clinical responses achieved by treating metastatic malignant …

Preclinical Evaluation of an 131I-Labeled Benzamide for Targeted Radiotherapy of Metastatic Melanoma

JL Joyal, JA Barrett, JC Marquis, J Chen, SM Hillier… - Cancer research, 2010 - AACR
Radiolabeled benzamides are attractive candidates for targeted radiotherapy of metastatic
melanoma as they bind melanin and exhibit high tumor uptake and retention. One such …

Biodistribution, radiation dosimetry, and clinical application of a melanin-targeted PET probe, 18F-P3BZA, in patients

X Ma, S Wang, S Wang, D Liu, X Zhao… - Journal of Nuclear …, 2019 - Soc Nuclear Med
N-(2-(diethylamino)-ethyl)-18F-5-fluoropicolinamide (18F-P3BZA) is a radiotracer that
demonstrates high binding selectivity and affinity in melanoma. The aim of the present study …

Synthesis and screening of bifunctional radiolabelled carborane-carbohydrate derivatives

AEC Green, SK Parker, JF Valliant - Journal of Organometallic Chemistry, 2009 - Elsevier
A new bifunctional carborane ligand was prepared as a platform for the development of
targeted molecular radioimaging and therapy agents. The carborane derivative was …