Peptide receptor therapies in neuroendocrine tumors
Neuroendocrine tumors (NETs) are relatively rare tumors, mainly originating from the
digestive system, able to produce bioactive amines and hormones. NETs tend to be slow …
digestive system, able to produce bioactive amines and hormones. NETs tend to be slow …
[HTML][HTML] Benzamide derivative radiotracers targeting melanin for melanoma imaging and therapy: Preclinical/clinical development and combination with other …
J Rouanet, M Quintana, P Auzeloux, F Cachin… - Pharmacology & …, 2021 - Elsevier
Cutaneous melanoma arises from proliferating melanocytes, cells specialized in the
production of melanin. This property means melanin can be considered as a target for …
production of melanin. This property means melanin can be considered as a target for …
Dopamine D2 receptor binding before and after treatment of major depression measured by [123I] IBZM SPECT
A Klimke, R Larisch, A Janz, H Vosberg… - Psychiatry Research …, 1999 - Elsevier
Fifteen patients fulfilling DSM-IV criteria for major depression were investigated with the
specific dopamine D2 receptor antagonist [123I] iodobenzamide (IBZM). Two single photon …
specific dopamine D2 receptor antagonist [123I] iodobenzamide (IBZM). Two single photon …
PET and SPECT imaging of melanoma: the state of the art
W Wei, EB Ehlerding, X Lan, Q Luo, W Cai - European journal of nuclear …, 2018 - Springer
Melanoma represents the most aggressive form of skin cancer, and its incidence continues
to rise worldwide. 18 F–FDG PET imaging has transformed diagnostic nuclear medicine and …
to rise worldwide. 18 F–FDG PET imaging has transformed diagnostic nuclear medicine and …
Development of 18F-Labeled Picolinamide Probes for PET Imaging of Malignant Melanoma
H Liu, S Liu, Z Miao, Z Deng, B Shen… - Journal of medicinal …, 2013 - ACS Publications
Melanoma is an aggressive skin cancer with worldwide increasing incidence. Development
of positron emission tomography (PET) probes for early detection of melanoma is critical for …
of positron emission tomography (PET) probes for early detection of melanoma is critical for …
High-contrast PET of melanoma using 18F-MEL050, a selective probe for melanin with predominantly renal clearance
D Denoyer, I Greguric, P Roselt, OC Neels… - Journal of Nuclear …, 2010 - Soc Nuclear Med
The aim of this study was to evaluate the novel probe 18F-6-fluoro-N-[2-(diethylamino) ethyl]
pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma …
pyridine-3-carboxamide (18F-MEL050) for the imaging of primary and metastatic melanoma …
Radiopharmaceutical therapy of patients with metastasized melanoma with the melanin-binding benzamide 131I-BA52
The performance of cytotoxic drugs is defined by their selectivity of uptake and action in
tumor tissue. Recent clinical responses achieved by treating metastatic malignant …
tumor tissue. Recent clinical responses achieved by treating metastatic malignant …
Preclinical Evaluation of an 131I-Labeled Benzamide for Targeted Radiotherapy of Metastatic Melanoma
JL Joyal, JA Barrett, JC Marquis, J Chen, SM Hillier… - Cancer research, 2010 - AACR
Radiolabeled benzamides are attractive candidates for targeted radiotherapy of metastatic
melanoma as they bind melanin and exhibit high tumor uptake and retention. One such …
melanoma as they bind melanin and exhibit high tumor uptake and retention. One such …
Biodistribution, radiation dosimetry, and clinical application of a melanin-targeted PET probe, 18F-P3BZA, in patients
X Ma, S Wang, S Wang, D Liu, X Zhao… - Journal of Nuclear …, 2019 - Soc Nuclear Med
N-(2-(diethylamino)-ethyl)-18F-5-fluoropicolinamide (18F-P3BZA) is a radiotracer that
demonstrates high binding selectivity and affinity in melanoma. The aim of the present study …
demonstrates high binding selectivity and affinity in melanoma. The aim of the present study …
Synthesis and screening of bifunctional radiolabelled carborane-carbohydrate derivatives
AEC Green, SK Parker, JF Valliant - Journal of Organometallic Chemistry, 2009 - Elsevier
A new bifunctional carborane ligand was prepared as a platform for the development of
targeted molecular radioimaging and therapy agents. The carborane derivative was …
targeted molecular radioimaging and therapy agents. The carborane derivative was …