To enhance the therapeutic efficacy of radioimmunotherapy of cancer, several pretargeting
strategies have been developed. In pretargeted radioimmunotherapy, the tumor is …

Immune checkpoint inhibitors and related molecules can achieve tumour regression, and
even prolonged survival, for a subset of cancer patients with an otherwise dire prognosis …

68Ge/68Ga radionuclide generators have been investigated for almost fifty years now, since
the cyclotronindependent availability of positron emitting 68Ga via the 68Ge/68Ga system …

Immuno-PET as a quantitative imaging procedure before or concomitant with
radioimmunotherapy is an attractive option to improve confirmation of tumor targeting and …

Antibodies have attained a central role as targeted therapeutics, with several significant
drugs on the market and many more in clinical development for oncological applications …

Purpose This study was aimed at establishing a list of radionuclides of interest for nuclear
medicine that can be produced in a high-intensity and high-energy cyclotron. Methods We …

The use of antibodies against tumor-associated cell surface antigens for the targeted
delivery of radionuclides was introduced> 20 years ago. Although encouraging results have …

During the last decade, the utilization of 68 Ga for the development of imaging agents has
increased considerably with the leading position in the oncology. The imaging of infection …

This invention relates to monovalent and multivalent, monospecific antibodies and to
multivalent, multispecific antibodies. One embodiment of these antibodies has one or more …

Pretargeting involves administration of a tumor-targeting monoclonal antibody (mAb)
covalently linked to a molecule having a high-affinity binding site for a rapidly distributed …