Resistance to chemotherapy is a critical issue in the management of breast cancer patients.
The nature of clinical drug resistance is likely to be multifactorial. However, in the last …

For cytotoxic agents to have an effect on tumor cells, drugs must first be transported into the
cell, potentially be metabolized to an active form, and interact appropriately with target …

PET is a unique form of diagnostic imaging that observes in vivo biologic changes using
radiopharmaceuticals that closely mimic endogenous molecules. 18F-FDG, which allows the …

The wide availability and the extensive use of screening mammography have resulted in an
earlier diagnosis of breast cancer and in a significant reduction in the relative risk of dying …

Molecular imaging is broadly defined as the characterization and measurement of biological
processes in living animals, model systems, and humans at the cellular and molecular level …

Various mechanisms are involved in multidrug resistance (MDR) for chemotherapeutic
drugs, such as the drug efflux pumps, P-glycoprotein (Pgp) and multidrug resistance …

BACKGROUND. Tumors with multidrug resistance (MDR) frequently up‐regulate efflux
proteins, including MDR‐associated protein (MRP‐1) and P‐glycoprotein (Pgp). MDR …

A major area of interest in nuclear medicine is the scintigraphic in vivo evaluation of complex
cellular processes involved in tumour growth, progression and response to treatment with …

PURPOSE: To evaluate the safety, tolerability, and pharmacokinetics of biricodar (VX-710),
an inhibitor of P-glycoprotein (P-gp) and multidrug resistance–associated protein (MRP1) …

This review aims at fostering comprehension and knowledge not only for expert physicians
who can skillfully handle various techniques for tumor imaging but also for young …