This article reviews the methods of pretargeting, which involve separating the targeting
antibody from the subsequent delivery of an imaging or therapeutic agent that binds to the …

To enhance the therapeutic efficacy of radioimmunotherapy of cancer, several pretargeting
strategies have been developed. In pretargeted radioimmunotherapy, the tumor is …

The invention relates to a method of preparing heteromul timeric polypeptides such as
bispeci? c antibodies, bispeci? c immunoadhesins and antibody-immunoadhesin chimeras …

Pretargeted radioimmunodiagnosis and radioimmunotherapy aim to efficiently combine
antitumor antibodies and medicinal radioisotopes for high-contrast imaging and high …

US7951917B1 - Method for making multispecific antibodies having heteromultimeric and
common components - Google Patents US7951917B1 - Method for making multispecific …

Labeled antibodies, as well as their fragments and antibody-derived recombinant constructs,
have long been proposed as general vectors to target radionuclides to tumor lesions for …

This article reviews recent preclinical and clinical advances in the use of pretargeting
methods for the radioimmunodetection and radioimmunotherapy of cancer. Whereas directly …

A valuable resource for researchers and workers in the fields of both pharmaceuticals and
biotechnology as well as undergraduates in biochemistry, applied biology, biomedical …

SUMMATION The pretargeting technique referred to as the Affinity Enhancement System
(AES) uses bispecific antibodies and radiolabeled bivalent haptens that bind cooperatively …

Pretargeting techniques that are based on the sequential administrations of bispecific
antitumor/antimetal chelate antibodies (BS-MAbs), a blocker to saturate the anti-chelate …