Cardiac neurotransmission imaging with SPECT and PET allows in vivo assessment of
presynaptic reuptake and neurotransmitter storage as well as of regional distribution and …

Neuroblastoma is the most common pediatric extracranial soft-tissue tumor, accounting for
approximately 8% of childhood malignancies. Its prognosis is widely variable, ranging from …

Findings from five independent studies-with close to 350 patients with pheochromocytoma
and more than 2 500 in whom the tumor was excluded-indicate that measurements of …

The norepinephrine transporter (NET) is a major target for the evaluation of the cardiac
sympathetic nerve system in patients with heart failure and Parkinson's disease. It is also …

Meta-iodobenzylguanidine (MIBG) is a structural analogue of the neurotransmitter
norepinephrine (NE) and is taken up by cells rich in sympathetic neurons by an active …

Purpose Regional cardiac sympathetic denervation (RCSD) associated with reduced
noradrenaline transporter (NAT) function has been linked to cardiac arrhythmia. This study …

A paired-label biodistribution was performed in athymic mice bearing SK-N-SH human
neuroblastoma xenografts to compare the tissue uptake of meta-[211At] …

18F-or 131I-labeled (4-fluoro-3-iodobenzyl) guanidine (FIBG) has been a promising yet
unattainable derivative of radioiodine-labeled meta-iodobenzylguanidine (MIBG), because …

We analyze the effects of protecting group (s) on the efficiency of aromatic 18 F-labeling of
guanidine-containing radiopharmaceuticals by quantum chemical methods. We elucidate …

With the goal of developing MIBG analogues with improved targeting properties especially
for oncologic applications, several radioiodinated ring-and side-chain-substituted MIBG …