Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement

R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

[HTML][HTML] Liposomes: clinical applications and potential for image-guided drug delivery

N Lamichhane, TS Udayakumar, WD D'Souza… - Molecules, 2018 - mdpi.com
Liposomes have been extensively studied and are used in the treatment of several
diseases. Liposomes improve the therapeutic efficacy by enhancing drug absorption while …

Nanoparticle approaches against bacterial infections

W Gao, S Thamphiwatana… - Wiley interdisciplinary …, 2014 - Wiley Online Library
Despite the wide success of antibiotics, the treatment of bacterial infections still faces
significant challenges, particularly the emergence of antibiotic resistance. As a result …

Lipid‐based nanotherapeutics for siRNA delivery

A Schroeder, CG Levins, C Cortez… - Journal of internal …, 2010 - Wiley Online Library
RNA interference (RNAi) is a specific gene‐silencing mechanism triggered by small
interfering RNA (siRNA). The application of RNAi in the clinic requires the development of …

Ultrasound, liposomes, and drug delivery: principles for using ultrasound to control the release of drugs from liposomes

A Schroeder, J Kost, Y Barenholz - Chemistry and physics of lipids, 2009 - Elsevier
Ultrasound is used in many medical applications, such as imaging, blood flow analysis,
dentistry, liposuction, tumor and fibroid ablation, and kidney stone disruption. In the past, low …

The enhanced permeability retention effect: a new paradigm for drug targeting in infection

EA Azzopardi, EL Ferguson… - Journal of Antimicrobial …, 2013 - academic.oup.com
Multidrug-resistant, Gram-negative infection is a major global determinant of morbidity,
mortality and cost of care. The advent of nanomedicine has enabled tailored engineering of …

Technetium‐99m radiochemistry for pharmaceutical applications

D Papagiannopoulou - Journal of Labelled Compounds and …, 2017 - Wiley Online Library
Technetium‐99m (99mTc) is a widely used radionuclide, and the development of 99mTc
imaging agents continues to be in demand. This overview discusses basic principles of …

Liposomes: quo vadis?

G Storm, DJA Crommelin - Pharmaceutical Science & Technology Today, 1998 - Elsevier
Liposomes have matured as a delivery system for therapeutic agents. It has taken two
decades to develop the liposome carrier concept to a pharmaceutical product level, but …

Advantages of liposomal delivery systems for anthracyclines

TM Allen, FJ Martin - Seminars in oncology, 2004 - Elsevier
Liposomes, closed vesicular structures consisting of one or more lipid bilayers, have
generated a great deal of interest as drug delivery vehicles. In particular, they have been …

Superoxide dismutase administration, a potential therapy against oxidative stress related diseases: several routes of supplementation and proposal of an original …

J Carillon, JM Rouanet, JP Cristol, R Brion - Pharmaceutical research, 2013 - Springer
Oxidative stress, involved in many diseases, is defined as an impaired balance between
reactive oxygen species (ROS) production and antioxidant defences. Antioxidant enzymes …