Somatostatin receptors: from signaling to clinical practice

M Theodoropoulou, GK Stalla - Frontiers in neuroendocrinology, 2013 - Elsevier
Somatostatin is a peptide with a potent and broad antisecretory action, which makes it an
invaluable drug target for the pharmacological management of pituitary adenomas and …

Basic aqueous chemistry of [M (OH2) 3 (CO) 3]+(M= Re, Tc) directed towards radiopharmaceutical application

R Alberto, R Schibli, R Waibel, U Abram… - Coordination Chemistry …, 1999 - Elsevier
A review on the synthesis and properties of the organometallic aqua-ion [M (OH2) 3 (CO)
3]+(M= Re, 99Tc, 99mTc), as relevant for radiopharmaceutical application, is presented …

Current use and future potential of organometallic radiopharmaceuticals

R Schibli, AP Schubiger - European journal of nuclear medicine and …, 2002 - Springer
Contrary to common belief, organometallic compounds exhibit remarkable stability in
aerobic and even diluted aqueous solutions. Technetium-sestamibi (Cardiolite) is one of the …

Stable one-step technetium-99m labeling of His-tagged recombinant proteins with a novel Tc (I)–carbonyl complex

R Waibel, R Alberto, J Willuda, R Finnern… - Nature …, 1999 - nature.com
We have developed a technetium labeling technology based on a new organometallic
chemistry, which involves simple mixing of the novel reagent, a 99m Tc (I)–carbonyl …

[BOOK][B] Bioinorganic chemistry: a short course

RM Roat-Malone - 2007 - books.google.com
An updated, practical guide to bioinorganic chemistry Bioinorganic Chemistry: A Short
Course, Second Edition provides the fundamentals of inorganic chemistry and biochemistry …

Metal complexes as diagnostic tools

DE Reichert, JS Lewis, CJ Anderson - Coordination Chemistry Reviews, 1999 - Elsevier
This review summarizes some of the developments of metal complexes and metal-complex-
bioconjugates for the diagnosis of disease states that have occurred over the past 10 years …

Receptor targeting for tumor localisation and therapy with radiopeptides

A Heppeler, S Froidevaux, AN Eberle… - Current medicinal …, 2000 - ingentaconnect.com
Receptor targeting with radiolabeled peptides has become very important in nuclear
oncology in the past few years. The most frequently used peptides in the clinic are analogs …

An intrapatient comparison of 99mTc-EDDA/HYNIC-TOC with 111In-DTPA-octreotide for diagnosis of somatostatin receptor-expressing tumors

M Gabriel, C Decristoforo, E Donnemiller… - Journal of nuclear …, 2003 - Soc Nuclear Med
The aim of this study was to compare the imaging abilities of the recently developed
somatostatin analog, 99mTc-hydrazinonicotinyl-Tyr3-octreotide (99mTc-HYNIC-TOC [99mTc …

[PDF][PDF] 99mTc-HYNIC-[Tyr3]-octreotide for imaging somatostatin-receptor-positive tumors: preclinical evaluation and comparison with 111In-octreotide

C Decristoforo, L Melendez-Alafort… - Journal of Nuclear …, 2000 - Soc Nuclear Med
% ID/g for 1111n-DTPA-octreotide. Tricine as coligand showed higher activity levels in
muscle, blood, and liver, whereas tricine nicotinicacid producedsignificantlevels of activity in …

99mTc Labeling of Highly Potent Small Peptides

S Liu, DS Edwards, JA Barrett - Bioconjugate chemistry, 1997 - ACS Publications
Peptides are compounds that contain amino acids (R-aminocarboxylic acids) linked by
amide (peptide) bonds. Designed by nature for stimulating, inhibiting, or regulating …