The folate receptor as a rational therapeutic target for personalized cancer treatment
Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …
Tumor immunoediting and immunosculpting pathways to cancer progression
JM Reiman, M Kmieciak, MH Manjili… - Seminars in cancer …, 2007 - Elsevier
Recent studies have suggested that a natural function of the immune system is to respond
and destroy aberrant, dysfunctional cells by a process called immunosurveillance. These …
and destroy aberrant, dysfunctional cells by a process called immunosurveillance. These …
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety
of cancers. The current development of folate-targeted cancer therapies has created the …
of cancers. The current development of folate-targeted cancer therapies has created the …
Design and Synthesis of [111In]DTPA−Folate for Use as a Tumor-Targeted Radiopharmaceutical
S Wang, J Luo, DA Lantrip, DJ Waters… - Bioconjugate …, 1997 - ACS Publications
Folate-conjugated metal chelates have been proposed as potential imaging agents for
cancers that overexpress folate receptors. In a previous study, folic acid was linked through …
cancers that overexpress folate receptors. In a previous study, folic acid was linked through …
Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects
Y Lu, PS Low - Journal of Controlled Release, 2003 - Elsevier
The cell surface receptor for the vitamin folic acid (termed the folate receptor), is often
elevated in cancers of the ovary, kidney, lung, mammary gland, brain, endometrium, and …
elevated in cancers of the ovary, kidney, lung, mammary gland, brain, endometrium, and …
Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor–positive solid tumors
RE Fisher, BA Siegel, SL Edell… - Journal of Nuclear …, 2008 - Soc Nuclear Med
99mTc-EC20 is a folate receptor (FR)–targeted imaging agent consisting of the vitamin
folate conjugated to 99mTc. FR is expressed on a variety of epithelial cancers, with …
folate conjugated to 99mTc. FR is expressed on a variety of epithelial cancers, with …
Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue
S Markert, S Lassmann, B Gabriel, M Klar… - Anticancer …, 2008 - ar.iiarjournals.org
Background: The goal of this study was to evaluate the expression pattern and intracellular
localization of alpha-folate receptor (α-FR) protein in human ovarian carcinoma compared …
localization of alpha-folate receptor (α-FR) protein in human ovarian carcinoma compared …
Folate-receptor-targeted radionuclide imaging agents
CY Ke, CJ Mathias, MA Green - Advanced drug delivery reviews, 2004 - Elsevier
The cell-membrane folate receptor is a potential molecular target for tumor-selective drug
delivery, including delivery of radiolabeled folate–chelate conjugates for diagnostic imaging …
delivery, including delivery of radiolabeled folate–chelate conjugates for diagnostic imaging …
[HTML][HTML] Immunotherapy in endometrial cancer: rationale, practice and perspectives
W Cao, X Ma, JV Fischer, C Sun, B Kong, Q Zhang - Biomarker Research, 2021 - Springer
Tumor immunotherapy has attracted more and more attention nowadays, and multiple
clinical trials have confirmed its effect in a variety of solid tumors. Immune checkpoint …
clinical trials have confirmed its effect in a variety of solid tumors. Immune checkpoint …
Synthesis of [99mTc]DTPA-Folate and Its Evaluation as a Folate-Receptor-Targeted Radiopharmaceutical
CJ Mathias, D Hubers, PS Low… - Bioconjugate …, 2000 - ACS Publications
A DTPA− folate conjugate was radiolabeled with 99mTc by stannous chloride reduction of
[99mTc] sodium pertechnetate in an aqueous solution of DTPA− folate. The radiochemical …
[99mTc] sodium pertechnetate in an aqueous solution of DTPA− folate. The radiochemical …