The folate receptor as a rational therapeutic target for personalized cancer treatment

YG Assaraf, CP Leamon, JA Reddy - Drug Resistance Updates, 2014 - Elsevier
Conventional cancer treatment modalities have several limitations including lack of sufficient
efficacy, serious untoward toxicity, as well as innate and acquired drug resistance. In …

Tumor immunoediting and immunosculpting pathways to cancer progression

JM Reiman, M Kmieciak, MH Manjili… - Seminars in cancer …, 2007 - Elsevier
Recent studies have suggested that a natural function of the immune system is to respond
and destroy aberrant, dysfunctional cells by a process called immunosurveillance. These …

Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay

N Parker, MJ Turk, E Westrick, JD Lewis, PS Low… - Analytical …, 2005 - Elsevier
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety
of cancers. The current development of folate-targeted cancer therapies has created the …

Design and Synthesis of [111In]DTPA−Folate for Use as a Tumor-Targeted Radiopharmaceutical

S Wang, J Luo, DA Lantrip, DJ Waters… - Bioconjugate …, 1997 - ACS Publications
Folate-conjugated metal chelates have been proposed as potential imaging agents for
cancers that overexpress folate receptors. In a previous study, folic acid was linked through …

Immunotherapy of folate receptor-expressing tumors: review of recent advances and future prospects

Y Lu, PS Low - Journal of Controlled Release, 2003 - Elsevier
The cell surface receptor for the vitamin folic acid (termed the folate receptor), is often
elevated in cancers of the ovary, kidney, lung, mammary gland, brain, endometrium, and …

Exploratory study of 99mTc-EC20 imaging for identifying patients with folate receptor–positive solid tumors

RE Fisher, BA Siegel, SL Edell… - Journal of Nuclear …, 2008 - Soc Nuclear Med
99mTc-EC20 is a folate receptor (FR)–targeted imaging agent consisting of the vitamin
folate conjugated to 99mTc. FR is expressed on a variety of epithelial cancers, with …

Alpha-folate receptor expression in epithelial ovarian carcinoma and non-neoplastic ovarian tissue

S Markert, S Lassmann, B Gabriel, M Klar… - Anticancer …, 2008 - ar.iiarjournals.org
Background: The goal of this study was to evaluate the expression pattern and intracellular
localization of alpha-folate receptor (α-FR) protein in human ovarian carcinoma compared …

Folate-receptor-targeted radionuclide imaging agents

CY Ke, CJ Mathias, MA Green - Advanced drug delivery reviews, 2004 - Elsevier
The cell-membrane folate receptor is a potential molecular target for tumor-selective drug
delivery, including delivery of radiolabeled folate–chelate conjugates for diagnostic imaging …

[HTML][HTML] Immunotherapy in endometrial cancer: rationale, practice and perspectives

W Cao, X Ma, JV Fischer, C Sun, B Kong, Q Zhang - Biomarker Research, 2021 - Springer
Tumor immunotherapy has attracted more and more attention nowadays, and multiple
clinical trials have confirmed its effect in a variety of solid tumors. Immune checkpoint …

Synthesis of [99mTc]DTPA-Folate and Its Evaluation as a Folate-Receptor-Targeted Radiopharmaceutical

CJ Mathias, D Hubers, PS Low… - Bioconjugate …, 2000 - ACS Publications
A DTPA− folate conjugate was radiolabeled with 99mTc by stannous chloride reduction of
[99mTc] sodium pertechnetate in an aqueous solution of DTPA− folate. The radiochemical …