INTRODUCTION: Tracer kinetic modeling used in conjunction with positron emission
tomography (PET) is an excellent tool for the noninvasive quantification of physiological …

Molecular imaging using PET provides a unique tool for noninvasively investigating the
biochemistry of living organs. The wide range of radiolabeled molecules makes it possible to …

Abstract Detection, localization, diagnosis, staging, and monitoring treatment responses are
the most important aspects and crucial procedures in diagnostic medicine and clinical …

Small-animal PET provides the opportunity to image brain activation during behavioral tasks
in animal models of human conditions. The present studies aimed to simplify behavioral …

Background Kinetic modeling of physiological function using imaging techniques requires
the accurate measurement of the time-activity curve of the tracer in plasma, known as the …

For cardiovascular research on rodents, small-animal PET has limitations because of the
inherent spatial resolution of the system and because of cardiac motion. A factor analysis …

Better mechanistic understanding of disease through mapping of the human and mouse
genomes enables rethinking of human infirmity. In the case of cancer, eg, we may begin to …

Derivation of the plasma time–activity curve in murine small-animal PET studies is a
challenging task when tracers that are sequestered by the myocardium are used, because …

In recent years, monoamine oxidase B (MAO-B) inhibitors have become widely used in the
treatment of early-stage Parkinson's disease. 11C-l-deprenyl PET has been used by others …

We previously developed a noninvasive technique for the quantification of
fluorodeoxyglucose (FDG) positron emission tomography (PET) images using an image …