Conditional human immunodeficiency virus transactivator of transcription protein expression induces depression-like effects and oxidative stress

JP McLaughlin, JJ Paris, D Mintzopoulos… - Biological Psychiatry …, 2017 - Elsevier
Background The prevalence of major depression in people with human immunodeficiency
virus (HIV)/acquired immunodeficiency syndrome is substantially higher than in the general …

Brain perfusion SPECT in the mouse: normal pattern according to gender and age

I Apostolova, A Wunder, U Dirnagl, R Michel… - Neuroimage, 2012 - Elsevier
Regional cerebral blood flow (rCBF) is a useful surrogate marker of neuronal activity and a
parameter of primary interest in the diagnosis of many diseases. The increasing use of …

Localization of glutathione and induction of glutathione synthesis-related proteins in mouse brain by low doses of γ-rays

S Kojima, O Matsuki, T Nomura, N Shimura… - Brain Research, 1998 - Elsevier
First, we determined the cerebral localization of reduced glutathione (GSH) in normal mice
by means of autoradiography using 99mTc-meso-hexamethyl propylene oxime. A highly …

Age-related changes of glutathione content, glucose transport and metabolism, and mitochondrial electron transfer function in mouse brain

T Sasaki, M Senda, S Kim, S Kojima… - Nuclear medicine and …, 2001 - Elsevier
To evaluate the oxidative stress-related parameters and to determine their order of
appearance in the brain aging process, radionuclide experiments were carried out on male …

Differential lung uptake of 99mTc-hexamethylpropyleneamine oxime and 99mTc-duramycin in the chronic hyperoxia rat model

AV Clough, SH Audi, ST Haworth… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Noninvasive radionuclide imaging has the potential to identify and assess mechanisms
involved in particular stages of lung injury that occur with acute respiratory distress …

Glutathione-mediated metabolism of technetium-99m SNS/S mixed ligand complexes: a proposed mechanism of brain retention

BA Nock, T Maina, D Yannoukakos… - Journal of medicinal …, 1999 - ACS Publications
Two series of [99mTc](SNS/S) mixed ligand complexes each carrying the N-
diethylaminoethyl or the N-ethyl-substituted bis (2-mercaptoethyl) amine ligand (SNS) are …

Radiosynthesis of an 18F‐fluoroglycosylated aminoferrocene for in‐vivo imaging of reactive oxygen species activity by PET

J Toms, V Reshetnikov, S Maschauer… - Journal of Labelled …, 2018 - Wiley Online Library
The imaging of reactive oxygen species (ROS) at the molecular level with high sensitivity
and specificity by positron emission tomography (PET) could be of enormous interest to …

Astrocytes as a Predominant Cellular Site of 99mTc-HMPAO Retention

S Zerarka, L Pellerin, D Slosman… - Journal of Cerebral …, 2001 - journals.sagepub.com
Technetium-99m-d, l-hexamethylpropylene amine oxime (99mTc-HMPAO) retention in the
brain monitored by single photon emission computed tomography (SPECT) is currently used …

[HTML][HTML] “Redox imaging” to distinguish cells with different proliferative indexes: Superoxide, hydroperoxides, and their ratio as potential biomarkers

Z Zhelev, E Georgieva, D Lazarova… - … Medicine and Cellular …, 2019 - hindawi.com
The present study was directed to the development of EPR methodology for distinguishing
cells with different proliferative activities, using “redox imaging.” Three nitroxide radicals …

Role of glutathione in lung retention of 99mTc-hexamethylpropyleneamine oxime in two unique rat models of hyperoxic lung injury

SH Audi, DL Roerig, ST Haworth… - Journal of Applied …, 2012 - journals.physiology.org
Rat exposure to 60% oxygen (O2) for 7 days (hyper-60) or to> 95% O2 for 2 days followed
by 24 h in room air (hyper-95R) confers susceptibility or tolerance, respectively, of the …