[HTML][HTML] A growing understanding of the role of muscarinic receptors in the molecular pathology and treatment of schizophrenia

B Dean, G Bakker, HR Ueda, AB Tobin… - Frontiers in Cellular …, 2023 - frontiersin.org
Pre-clinical models, postmortem and neuroimaging studies all support a role for muscarinic
receptors in the molecular pathology of schizophrenia. From these data it was proposed that …

ICRP publication 128: radiation dose to patients from radiopharmaceuticals: a compendium of current information related to frequently used substances

S Mattsson, L Johansson… - Annals of the …, 2015 - journals.sagepub.com
This report provides a compendium of current information relating to radiation dose to
patients, including biokinetic models, biokinetic data, dose coefficients for organ and tissue …

Iodine-123 labelled radiopharmaceuticals and single-photon emission tomography: a natural liaison

MH Bourguignon, EKJ Pauwels, C Loc'h… - European journal of …, 1997 - Springer
Most nuclear medicine departments possess one or more imaging apparatuses for single-
photon emission tomography (SPET). Molecules of biological interest to assess metabolism …

[HTML][HTML] Relationship between muscarinic M1 receptor binding and cognition in medication-free subjects with psychosis

G Bakker, C Vingerhoets, D Boucherie, M Caan… - NeuroImage: Clinical, 2018 - Elsevier
Background It is still unclear which underlying mechanisms are involved in cognitive deficits
of psychotic disorders. Pro-cognitive effects of muscarinic M 1 receptor agonists suggest …

PET Imaging of brain muscarinic receptors with 18F-Fluorobenzyl-Dexetimide: A first in human study

CC Rowe, N Krishnadas, U Ackermann, V Doré… - Psychiatry Research …, 2021 - Elsevier
M1 and M4 muscarinic receptor (mAChR) agonists are under development for the treatment
of schizophrenia, Alzheimer's and Parkinson's disease. We performed first-in-human PET …

Higher occupancy of muscarinic receptors by olanzapine than risperidone in patients with schizophrenia: A [123I]-IDEX SPECT study

J Lavalaye, J Booij, D Linszen, L Reneman… - …, 2001 - Springer
Rationale: In vitro data have shown anticholinergic properties of the atypical antipsychotic
drug olanzapine. Substantial occupancy of muscarinic receptors may be an explanation for …

[HTML][HTML] Human biodistribution and internal dosimetry of 4-[ 18F]fluorobenzyl-dexetimide: a PET radiopharmaceutical for imaging muscarinic acetylcholine receptors …

CD Pain, GJ O'Keefe, U Ackermann, V Dore… - EJNMMI research, 2020 - Springer
Abstract Background 4-[18 F] fluorobenzyl dexetimide (F-DEX) is the first non-subtype
selective fluorine-18 labelled tracer for muscarinic receptors (mAChR) used in humans. A …

123I-iododexetimide preferentially binds to the muscarinic receptor subtype M1 in vivo

G Bakker, WA Vingerhoets… - Journal of Nuclear …, 2015 - Soc Nuclear Med
The muscarinic M1 receptor (M1R) is highly involved in cognition, and selective M1 agonists
have procognitive properties. Loss of M1R has been found in postmortem brain tissue for …

In vitro pharmacological characterization and in vivo validation of LSN3172176 a novel M1 selective muscarinic receptor agonist tracer molecule for positron emission …

AJ Mogg, T Eessalu, M Johnson, R Wright… - … of Pharmacology and …, 2018 - ASPET
In the search for improved symptomatic treatment options for neurodegenerative and
neuropsychiatric diseases, muscarinic acetylcholine M1 receptors (M1 mAChRs) have …

Sequential 123I-iododexetimide scans in temporal lobe epilepsy: comparison with neuroimaging scans (MR imaging and 18F-FDG PET imaging)

A Mohamed, S Eberl, MJ Fulham, M Kassiou… - European journal of …, 2005 - Springer
Purpose Muscarinic acetylcholine receptors (mAChRs) play an important role in the
generation of seizures. Single-photon emission computed tomography (SPECT) with 123 I …