Pathway-specific dopamine abnormalities in schizophrenia
JJ Weinstein, MO Chohan, M Slifstein, LS Kegeles… - Biological …, 2017 - Elsevier
In light of the clinical evidence implicating dopamine in schizophrenia and the prominent
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …
hypotheses put forth regarding alterations in dopaminergic transmission in this disease …
Do novel antipsychotics have similar pharmacological characteristics? A review of the evidence
J Arnt, T Skarsfeldt - Neuropsychopharmacology, 1998 - nature.com
The pharmacological properties of the novel antipsychotic drugs (APDs) risperidone,
sertindole, olanzapine, quetiapine, ziprasidone, remoxipride, and amperozide are reviewed …
sertindole, olanzapine, quetiapine, ziprasidone, remoxipride, and amperozide are reviewed …
Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
V Kaasinen, H Vilkman, J Hietala, K Nċgren… - Neurobiology of …, 2000 - Elsevier
Loss of dopamine D2-like receptors in the striatum has been associated with both normal
human aging and impairment of cognitive and motor functions in the elderly. To investigate …
human aging and impairment of cognitive and motor functions in the elderly. To investigate …
Clinical validation of 18F-AZD4694, an amyloid-β–specific PET radioligand
Z Cselényi, ME Jönhagen, A Forsberg… - Journal of Nuclear …, 2012 - Soc Nuclear Med
Pioneered with the invention of 11C-Pittsburgh compound B, amyloid-β imaging using PET
has facilitated research in Alzheimer disease (AD). This imaging approach has promise for …
has facilitated research in Alzheimer disease (AD). This imaging approach has promise for …
[PDF][PDF] PET evaluation of the dopamine system of the human brain
ND Volkow, JS Fowler, SJ Gatley, J Logan… - Journal of Nuclear …, 1996 - Soc Nuclear Med
Dopamine plays a pivotal role in the regulation and control of movement, motivation and
cognition. It also is closely linked to reward, reinforcement and addiction. Abnormalities in …
cognition. It also is closely linked to reward, reinforcement and addiction. Abnormalities in …
Imaging D2 receptor occupancy by endogenous dopamine in humans
M Laruelle, CD D'Souza, RM Baldwin… - …, 1997 - nature.com
The impact of endogenous dopamine on in vivo measurement of D 2 receptors in humans
was evaluated with single photon emission computerized tomography (SPECT), by …
was evaluated with single photon emission computerized tomography (SPECT), by …
Prefrontal and striatal dopamine release are inversely correlated in schizophrenia
WG Frankle, M Himes, NS Mason, CA Mathis… - Biological …, 2022 - Elsevier
Background The dopamine (DA) hypothesis postulates hyperactivity of subcortical DA
transmission and hypoactivity of cortical DA in schizophrenia (SCH). Positron emission …
transmission and hypoactivity of cortical DA in schizophrenia (SCH). Positron emission …
[HTML][HTML] Thalamic dopamine D2-receptor availability in schizophrenia: a study on antipsychotic-naive patients with first-episode psychosis and a meta-analysis
P Plavén-Sigray, P Ikonen Victorsson, A Santillo… - Molecular …, 2022 - nature.com
Pharmacological and genetic evidence support a role for an involvement of the dopamine
D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging …
D2-receptor (D2-R) in the pathophysiology of schizophrenia. Previous molecular imaging …
[HTML][HTML] Molecular imaging of opioid and dopamine systems: insights into the pharmacogenetics of opioid use disorders
JA Burns, DS Kroll, DE Feldman, C Kure Liu… - Frontiers in …, 2019 - frontiersin.org
Opioid use in the United States has steadily risen since the 1990s, along with staggering
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid …
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid …
Role of sodium channel inhibition in neuroprotection: effect of vinpocetine
Vinpocetine (ethyl apovincaminate) discovered during the late 1960s has successfully been
used in the treatment of central nervous system disorders of cerebrovascular origin for …
used in the treatment of central nervous system disorders of cerebrovascular origin for …