Summary Dithiocarbamates (R2CNS2−) are a versatile class of monoanionic 1, 1‐dithio
ligands and as they are easily prepared, a wide range of chemistry has been developed …

The favorable nuclear properties in combination with the rich coordination chemistry make
technetium-99m the radioisotope of choice for the development of myocardial perfusion …

Lead has been used as a heavy atom derivative to solve the phase problem in the crystal
structures of a variety of protein including the calcium proteins calmodulin and …

Abstract 99m Tc radiopharmaceuticals play an important role in widespread applications of
nuclear medicine. When 99m Tc radiopharmaceuticals first came into use, major efforts were …

Increasing the potency of therapeutic compounds, while limiting side-effects, is a common
goal in medicinal chemistry. Ligands that effectively bind metal ions and also include …

99mTc labeled myocardial perfusion tracers have significantly advanced the field of
noninvasive diagnostic evaluation and risk stratification of patients with known or suspected …

The advent of myocardial perfusion imaging 30 years ago was a major landmark, which
heralded the emergence of the field of nuclear cardiology into clinical practice. Over the …

By the time cardiotoxicity-associated cardiac dysfunction is detectable by echocardiography
it is often beyond meaningful intervention. 99mTc-sestamibi is used clinically to image …

With the emergence of new diseases, a lot of advancements have been made in diagnosis
such as identification of new biomarkers, imaging techniques, radioisotopes tracking, and …

Over the past 30 years dithiocarbamate ligands have found application in
radiopharmaceutical metal-ligand complexes to image a range of disease states. The vast …