After decades of rapid increase, the rate of obesity in adults in the USA is beginning to slow
and the rate of childhood obesity is stabilizing. Despite these improvements, the obesity …

Abstract Purpose of Review The goal of the present paper is to review current literature
supporting the occurrence of fundamental changes in brain energy metabolism during the …

OBJECTIVE To test whether brain fatty acid uptake is enhanced in obese subjects with
metabolic syndrome (MS) and whether weight reduction modifies it. RESEARCH DESIGN …

BACKGROUND & AIMS: Hepatic lipotoxicity results from and contributes to obesity-related
disorders. It is a challenge to study human metabolism of fatty acids (FAs) in the liver. We …

A method, model, and “operational equations” are described to quantify in vivo turnover
rates and half-lives of fatty acids within brain phospholipids, as well as rates of incorporation …

The presence of positron emission tomography (PET) centers at most major hospitals
worldwide, along with the improvement of PET scanner sensitivity and the introduction of …

The central nervous system mediates energy balance (energy intake and energy
expenditure) in the body; the hypothalamus has a key role in this process. Recent evidence …

Introduction High-fat diets increase risk for Alzheimer's disease, but individuals with the risk
gene APOE ε4 (E4) paradoxically have improved memory soon after high fat feeding. Little is …

The ketogenic diet is a clinically and experimentally effective anti-epileptic treatment whose
molecular mechanism (s) of action remain to be elucidated. As a first step in defining its …

Using a method and model developed in our laboratory to quantitatively study brain
phospholipid metabolism, in vivo rates of incorporation and turnover of docosahexaenoic …