Doxorubicin (Adriamycin) has been used in oncologic practice since the late 1960s. It held
promise as a powerful drug in the fight against cancer. The tumors most commonly …

Neuronal function and innervation density is regulated by target organ-derived neurotrophic
factors. Although cardiac hypertrophy drastically alternates the expression of various growth …

Abstract Background I-123 meta-iodobenzylguanidine (MIBG) imaging has long been
employed to noninvasively assess the integrity of human norepinephrine transporter-1 and …

Cardiac denervation is associated with progressive left ventricular (LV) dysfunction,
ventricular arrhythmias, and sudden cardiac death (SCD) in heart failure (HF). In this regard …

Doxorubicin is one of the most useful anticancer agents, but its repeated administration can
induce irreversible cardiomyopathy as a major complication. The purpose of this study was …

Objectives: We investigated the relationship between iodine-123-metaiodobenzylguanidine
(123I-MIBG) findings and myocardial contractile reserve in patients with mild to moderate …

Background We sought to investigate whether β-blockers exert a presynaptic effect in the
myocardium as measured by 123I-metaiodobenzylguanidine. Methods The study comprised …

This study assessed the prognostic value of Iodine-123-metaiodobenzylguanidine (MIBG)
imaging and of the plasma level of cardiac natriuretic peptides in patients with left ventricular …

MIBG washoutfor infarcted (low perfuskn, low MIBG uptake) and remote myocardium
(normal perfusion, high MIBG uptake), whereas the borderzone (normalperfusion, low MIBG …

Background During anthracycline treatment of cancer, there is a lack for biomarkers of
cardiotoxicity besides the cardiac dysfunction. The objective of the present study was to …