Most experimental work in the space of bioconjugation chemistry focuses on using new
methods to construct covalent bonds between a cargo molecule and a protein of interest …

The ability to modify biologically active molecules such as antibodies with drug molecules,
fluorophores or radionuclides is crucial in drug discovery and target identification. Classic …

The creation of discrete, covalent bonds between a protein and a functional molecule like a
drug, fluorophore, or radiolabeled complex is essential for making state-of-the-art tools that …

At the present time, there are three radiolabeled antibodies that have been approved by the
US Food and Drug Administration (FDA) for imaging of cancer, a fourth commercially …

Monoclonal antibodies (mAbs), immunoglobulin fragments, and other proteins are important
scaffolds in the development of radiopharmaceuticals for diagnostic immuno‐positron …

The murine monoclonal anti-CA125 antibody MAb-B43. 13 has previously been
administered as an immunoscintigraphic agent in order to monitor recurrence of ovarian …

In an alternative approach for radiotracer design, a photoactivatable HBED-CC-PEG3-ArN3
chelate was synthesized and photoconjugated to the anti-c-MET antibody MetMAb …

This prospective, open-label, pilot phase 2 study examined the clinical and immunologic
effects of oregovomab (OvaRex®) in heavily pretreated patients with recurrent ovarian …

Intravenous injection of the murine monoclonal anti-CA125 antibody B43. 13 (Ovarex: Ab 1)
into ovarian cancer patients led to the induction of an idiotypic network. Of the 75 patients …

A method for the simultaneous (one-step) photochemical conjugation and 89 Zr-
radiolabeling of antibodies is introduced. A photoactivatable chelate based on the …